Efficacy and tolerability of Ketotifen in Nepalese asthmatic children: a clinical study

KN, Shakya; P, Joshi; A, Piya; MR, Baral

Publication:
Efficacy and tolerability of Ketotifen in Nepalese asthmatic children: a clinical study

creativeworkseries.issn	1812-2027
dc.contributor.author	KN, Shakya
dc.contributor.author	P, Joshi
dc.contributor.author	A, Piya
dc.contributor.author	MR, Baral
dc.date.accessioned	2025-07-13T06:15:57Z
dc.date.available	2025-07-13T06:15:57Z
dc.date.issued	2003
dc.description.abstract	Objective To assess the efficacy of Ketotifen in asthmatic children and to record its adverse effects, if any. Design Prospective clinical trial. Setting Pediatric asthma follow up clinic of a teaching hospital. Participants 23 asthmatic children between 3 and 15 years; 100% completed the trial on full protocol. Interventions Ketotifen 1mg (adjusted according to body weight, 50 mcg/kg/dose) orally twice daily for 9 months. Main Outcome measures Primary outcome: Decrease in frequency of asthmatic attacks and severity of exacerbations with improvements in peak expiratory flow rates (PEFR). Other measures included decrease in bronchodilator requirement, steroid doses and parental perception regarding patient quality of life. Results 34.78% children were symptom free by the end of 2nd 3 months and 65.21% had no further attack by the end of 3 rd 3 months of Ketotifen prophylaxis. Those children with activity and sleep ‘affected’ (8.69%) and ‘may be affected’ (30.43%) together improved to ‘may be affected’ group (21.73%) by the end of 2nd 3 months and further reduced to 8.69% by the conclusion of 3 rd 3 months. The duration of exacerbations was reduced in the remaining cases. Variability of PEFR decreased from 26.08% to 8.69% of children after the 3 rd 3 months of Ketotifen prophylaxis. No significant adverse effect of therapy was observed during the study. Conclusion Oral Ketotifen is effective and well tolerated for use in prophylactic treatment of bronchial asthma in children. Key Words: Ketotifen, Asthma, Prophylaxis, Efficacy.
dc.identifier.uri	https://hdl.handle.net/20.500.14572/127
dc.language.iso	en_US
dc.publisher	Kathmandu University
dc.title	Efficacy and tolerability of Ketotifen in Nepalese asthmatic children: a clinical study
dc.type	Article
dspace.entity.type	Publication
local.article.type	Original Article
oaire.citation.endPage	247
oaire.citation.startPage	242
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