Publication: Clinical study of sentinel lymph node biopsy in early uterine cervical carcinoma
Date
2005
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Background: Radical hysterectomy and complete pelvic lymphadenectomy is the standard treatment for early
cervical carcinoma. But the rate of pelvic and paraaortic nodal metastasis is found to be low, pointing that most of
the patients possibly undergo unnecessary nodal dissection.
Aim: To study the value of sentinel lymph nodes (SLNs) in prediction of the pelvic lymph node status and to
determine the significance of SLN detection in pelvic lymph node dissection in patients with early stage cervical
carcinoma.
Settings and design: Retrospective study.
Methods: From August 2002 to August 2004, 20 patients with early stage cervical carcinoma, planned to undergo
radical hysterectomy and extensive pelvic lymph node dissection received an intracervical injection of a blue dye to
identify and perform resection of SLN. The SLNs were pathologically compared with non-SLNs with frozen
section, paraffin section, and anti-cytokeratin immunohistochemical staining.
Results: Out of 20 patients, SLNs were detected in 15 patients. A total of 46 SLNs were identified and the mean
was 3 per patient. The detection rate of SLN was 75%. Sensitivity, specificity and accuracy of the SLN biopsy were
75%, 100% and 95%, respectively.
Conclusion: SLN detection can predict the pelvic lymph node status in early stage cervical carcinoma, but the
feasibility and safety of this technique to substitute conventional surgical modality should be evaluated by large
series of prospective studies.
Keywords: Cervical cancer; Sentinel lymph node biopsy; Lymph node excision