Article:
Socio-demographic characteristics and clinical profile in sickle cell disease patients

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creativeworkseries.issn1999-6217
dc.contributor.authorJoshi, Gauri Datt
dc.contributor.authorKamar, Sher Bahadur
dc.contributor.authorMishra, Pradip
dc.contributor.authorPandey, Hem Raj
dc.contributor.authorShah, Yogendra
dc.contributor.authorMandal, Ananda Kumar
dc.contributor.authorSingh, Ankit Kumar
dc.contributor.authorKhanal, Eak Dev
dc.contributor.authorPandey, Kishor
dc.contributor.authorDumre, Shyam Prakash
dc.contributor.authorPandey, Basu Dev
dc.contributor.authorMarasini, Bishnu Prasad
dc.contributor.authorJoshi, Pramod
dc.creator.affiliationDepartment of Social development, Seti Provincial Hospital, Dhangahdi, Kailali, Nepal
dc.creator.affiliationDepartment of Internal Medicine, Seti Provincial Hospital, Dhangahdi, Kailali, Nepal.
dc.creator.affiliationDepartment of Paediatrics, Seti Provincial Hospital, Dhangadhi, Kailali, Nepal.
dc.creator.affiliationDepartment of Paediatrics, Seti Provincial Hospital, Dhangadhi, Kailali, Nepal.
dc.creator.affiliation4 Planetary Health Research Center, Kathmandu, Nepal.
dc.creator.affiliationCentral Department of Zoology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
dc.creator.affiliationMinistry of Health and Population, Kathmandu, Nepal.
dc.creator.affiliationCentral Department of Zoology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
dc.creator.affiliation8 Central Department of Microbiology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
dc.creator.affiliationDEJIMA Infectious Disease Research Alliance, Nagasaki University, Nagasaki, Japan.
dc.creator.affiliationNepal Health Research Council, Kathmandu, Nepal
dc.creator.affiliationNepal Health Research Council, Kathmandu, Nepal.
dc.date.accessioned2026-09-15T09:50:23Z
dc.date.available2026-09-15T09:50:23Z
dc.date.issued2025
dc.description.abstractAbstract: Background: Sickle cell disease (SCD) is a significant public health issue in Nepal, predominantly affecting the Tharu community in the Mid-Western and Sudurpaschim province. This study was design to understand the socio-demographic characteristics and symptoms of SCD patients attending the health camp conducted by Seti Provincial Hospital in Sudurpashchim Province, Nepal. Methods: This study was cross-sectional study conducted at Sudurpashchim Province of Nepal visiting in Seti provincial Hospital during the period of free health camp organized by Hospital. After ethical clearance, patients were enrolled based on inclusion and exclusion criteria, and their demographic, epidemiological, and clinical profiles were recorded using a structured questionnaire. Results: Among 119 patients with SCD, the mean age was 22.58 years, with a majority (58.8%) being female. Most patients (45.37%) belonged to the upper lower socioeconomic class. The most common symptom was musculoskeletal pain, weakness, and fever (30.5%), followed by jaundice, chest pain, and vertigo (21.84%). Additionally, 15.96% experienced weakness, nausea, breathing difficulties, and fever; 12.60% reported weight loss, low hemoglobin, and chest pain; 10.08% had backache, joint pain, fever, and headache; and 9.24% experienced knee pain, fever, anemia, and vertigo. Conclusions: SCD is seen in younger patients in Sudurpashchim Province, especially Kailali and Kanchanpur Districts with Tharu communities are more affected. Major systemic manifestations of SCD include pain crisis, hemolytic crisis, acute chest syndrome, hepatopathy and AVN of hip. The government of Nepal should implement policies focus for treatment and pain management within the current health system, to minimize, control, and prevent the high burden of SCD in the Tharu communities.
dc.identifier.doihttps://doi.org/10.33314/jnhrc.v23i02.4702
dc.identifier.urihttps://hdl.handle.net/20.500.14572/7699
dc.language.isoen_US
dc.publisherNepal Health Research Council
dc.subjectHaemolytic anemia
dc.subjectNepal
dc.subjectPain crises
dc.subjectSickle cell disease
dc.titleSocio-demographic characteristics and clinical profile in sickle cell disease patients
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage368
oaire.citation.startPage361
relation.isJournalIssueOfPublication5df7ea21-413e-4c7e-92f6-f85d6e7a64ef
relation.isJournalIssueOfPublication.latestForDiscovery5df7ea21-413e-4c7e-92f6-f85d6e7a64ef
relation.isJournalOfPublication40bd2739-8b19-447c-be60-723a1bdd1dcd

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