Publication: Recent advancement in drug delivery system
Date
2008
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu university
Abstract
Abstract
Ease of drug administration, safety, affordability and efficacy are the major concerns in pharmacotherapy leading to
exploration of better drug delivery systems. Liposomes are lyotropic liquid crystals composed mainly of ampiphilic
bilayers and these are more frequently used as drug carriers. Liposomes help reduce the toxicity and deliver the drug
to the target tissue. So far, liposomes have been the most intensively studied lipid-based delivery system. In liposomes,
a hydrophilic drug can be trapped in aqueous interior or channels between successive phospholipids bilayers whereas
a hydrophobic drug can reside with the bilayer itself. The non-toxic and nonimmunogenic bilayers dissipate allowing
the diffusion of the drug into the tissues. Attachment of polyethyl glycol to the surface of liposome (known as stealth
liposome) aids in the better targeting of the drug to the tissues. Pegylated proteins and polymers of lactic and glycolic
acids have been well studied as drug carriers and found to be resistant to phagocytosis and complement activation. Newer
DNA based strategies including DNA vaccination and antisense oligonucleotides and immunomodulation show good
results for new therapeutic systems. Though the DNA based therapeutic systems have high selectivity and specificity
with few adverse effects, these systems are so far restricted to animal models and clinical trials.
Key words: stealth liposome, microspheres, pegylated protein, polymers, antibody, DNA
Description
Paudel KR1, Rauniar GP2 , Bhattacharya SK3, Das BP 4
1Junior Resident, 2,3 Professors, Department of Pharmacology, 4 Professor and Hospital Director, B. P. Koirala Institute of Health Sciences, Dharan, Nepal