Publication: Evaluation of non-HDL-c and total cholesterol: HDL-c Ratio as Cumulative Marker of Cardiovascular Risk in Diabetes Mellitus
Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Cardiovascular disease (CVD), is the primary cause of morbidity and mortality in
patients with diabetes and have approximately - two to four times higher CVD rate
than adult without diabetes. Low density lipoprotein cholesterol (LDL-C) is primarily
used as the marker of cardiovascular risk in diabetes despite its several limitations.
Although several newer markers of CVD are emerging, no marker has been established
in Nepal.
Objectives
The study was designed to evaluate the non-high-density-lipoprotein- cholesterol(Non-
HDL-C) and Total Cholesterol to High density lipoprotein cholesterol (TC:HDL-C ratio) as
CVD risk marker in diabetes mellitus.
Methods
The study was conducted in the Department of Bbiochemistry, Kathmandu University
School of Medical Sciences. The study comprised of 76 diabetic subjects and 60 non-
diabetic subjects. The anthropometric and biochemical parameters were measured.
The Non-HDL-C and TC:HDL-C ratio were also calculated employing their respective
formula.
Results
Body mass index (BMI), waist circumference (WC), blood pressure and lipid parameters
were significantly different between diabetic subjects and non-diabetic subjects.
There was increased non-HDL-C and TC:HDL-C ratio in subjects with diabetes mellitus.
Furthermore, statistically significant correlations of non-HDL-C and TC:HDL-C ratio were
obtained with BMI, WC, total cholesterol, HDL-C and LDL-C in diabetic subjects.
Conclusions
The present study observation revealed that the Non-HDL-C and TC: HDL-C strongly
correlate with established independent risk factors such as obesity(WC), elevated
blood pressure, HDL-C and LDL-C in diabetes. Thus, the evaluation of Non-HDL-C and
TC: HDL-C ratio can be used as the simple, cost-effective and cumulative marker of
cardiovascular risk in diabetes mellitus.
Key Words
cardiovascular risk, diabetes mellitus, Hypertension, lipid profile, Obesity, Non-HDL-
cholesterol
Description
Aryal M1, Poudel A2, Satyal B2, Gyawali P4, Pokheral BR5, Raut BK6, Adhikari RK7, Koju R8
1,4,6 Department of Biochemistry, 2,3 Faculty of Human Biology, 5,8 Department of Internal Medicine, 7Department of Community Medicine, Dhulikhel Hospital-Kathmandu University Hospital, Dhulikhel, Nepal