Publication: Oxidative stress and antioxidant status in cardiovascular diseases in population of western Nepal
Date
2006
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Objectives: To observe if there is any connectivity between oxidative stress and cardiovascular diseases (CVDs).
Materials and methods: Patients suffering from different cardiovascular diseases (hypertension, ischemic heart
disease, rheumatic heart disease) attending Manipal Teaching Hospital, Pokhara and strictly matched controls were
selected for this study. Oxidative stress (OS) was measured by plasma thiobarbituric acid reacting substances
(TBARS) where as antioxidant status was measured by estimating vitamin E, vitamin C and total antioxidant
activity (TAA) in plasma.
Results: The mean level of TBARS, TAA, vitamin C and E were 2.20+0.43 nmol/ml, 547+98 μmol/l, 0.88+0.15
mg/dl and 0.75+0.20 mg/dl respectively in patients. The respective values in controls were 1.86+0.43 nmol/ml,
859+139 μmol/l, 0.94+0.15 mg/dl and 1.10+0.30 mg/dl. Although the OS seems to be raised in patients, is
practically insufficient to oxidize biomolecules and induce CVDs. Despite vitamin C and E levels being well within
normal limits, the TAA was significantly and considerably lower in patients. This is a highly interesting observation
suggesting that dietary antioxidants other than these vitamins were preferentially consumed to control OS because
procedure for TAA used in this study practically measures only total dietary antioxidants.
Conclusion: OS does not appear to be an etiological factor for the cardiovascular diseases; rather slightly raised OS
in patients seems to be a consequence. Further the raised OS was not due to lower nutrient antioxidant (vit. C and
vit. E) in the local population studied herein.
Key words: Oxidative stress, cardiovascular diseases, vitamin C, vitamin E, total antioxidant activity.
Description
Risal S 1
, Adhikari D 2, Alurkar VM 3
, Singh PP 4
1 Lecturer, Department of Biochemistry, Nepal Medical College, Attarkhel, Jorpati, Kathmandu, 2Lecturer,
Department of Biochemistry, 3
Prof. and HOD, Department of Medicine, 4Professor and HoD, Department of
Biochemistry, Manipal College of Medical Sciences, Pokhara