Publication: Management of antitubercular drugs-induced hepatotoxicity and therapy reintroduction strategy in a TB clinic of Nepal
| creativeworkseries.issn | 1812-2027 | |
| dc.contributor.author | Shakya, R | |
| dc.contributor.author | Rao, BS | |
| dc.contributor.author | Shrestha, B | |
| dc.date.accessioned | 2025-07-16T09:08:45Z | |
| dc.date.available | 2025-07-16T09:08:45Z | |
| dc.date.issued | 2005 | |
| dc.description.abstract | Background: PZA, INH and R have potential for hepatotoxic side effects. Although anti-tuberculosis drug-induced hepatotoxicity is well known, there is no agreement on the clinical approach for cases in whom hepatotoxicity has developed. Objective: To study the management of anti-TB-drugs induced hepatotoxicity and the standard anti-TB drugs therapy reintroduction procedure. Design: In prospective cohort analysis, 4 patients with active TB infection had developed anti-TB drugs induced hepatotoxicity. Retreatment of therapy was done on the basis of severity of hepatitis. If damage is mild, all the drugs were reintroduced at once in a tapering dose and if patient’s condition is worse, INH and E is introduced in lower dose, later increasing the dose and the number of drugs. Results: All the patients tolerated anti-TB drugs well after reintroduction. There was no incidence of recurrence. All the patients completed their 8 months treatment regimen and all are cured. Conclusion: Timely detection and temporary withdrawal of the offending agent can completely cure anti-TB drugs-induced hepatotoxicity. The recurrence of hepatotoxicity is rare if reintroduction in done in a well planned manner. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/292 | |
| dc.language.iso | en_US | |
| dc.publisher | Kathmandu University | |
| dc.title | Management of antitubercular drugs-induced hepatotoxicity and therapy reintroduction strategy in a TB clinic of Nepal | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 49 | |
| oaire.citation.startPage | 45 | |
| relation.isJournalIssueOfPublication | 70ef107d-d5d0-4c83-897d-8b9912b49180 | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 70ef107d-d5d0-4c83-897d-8b9912b49180 | |
| relation.isJournalOfPublication | a782b7ff-cf89-4178-ad1c-11ed89cfe1bd |