Publication: Is Central Nervous System an Immune-Privileged Site?
Date
2013
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
The central nervous system (CNS) was once considered to be an immune-privileged
area. However, increasing evidence shows that the central nervous system is not
an immune-privileged but is an active surveillance site. There is a bi-directional
communication between the central nervous system and immune system.
Normally, immune cells migrate into the central nervous system microenvironment
through choroid plexus and interact with the central nervous system resident cells
through either through neuromediators or immunomediators. This finding has led
to a significant interest in neuroimmunological interactions and investigation onto
the role of the immune system in the pathology of various neurological disorders
and examine whether it can be targeted to produce novel therapeutic strategies.
KEYWORDS
Central nervous system, immune-privileged, blood-brain barrier, immune cells and
lymphocytes
Description
Shrestha R,1,2,5 Millington O,3 Brewer J,4 Bushell T5
Department of Pharmacology
Dhulikhel Hospital-Kathmandu University Hospital
Kathmandu University School of Medical Sciences Dhulikhel, Kavre, Nepal
2Lilly Research Centre, Eli Lilly and Company, Surrey, UK
3Centre of Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
4Institute of Infection, Immunity and Inflammation College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
5Centre for Neuroscience, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK