Article:
Efficacy of prophylactic use of ciprofloxacin and metronidazole in mild and moderately severe acute pancreatitis

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorAmrendra Kumar Mandal
dc.contributor.authorSitaram Chaudhary
dc.contributor.authorBarun Shrestha
dc.contributor.authorMukesh Sharma Paudel
dc.contributor.authorNandu Silwal Paudel
dc.contributor.authorBidhan Nidhi Paudel
dc.contributor.authorBikash Bhattarai
dc.contributor.authorSunil Kumar Ray
dc.contributor.authorNeetu Mandal Ray
dc.creator.affiliationGastroenterology Unit, Department of Medicine, NAMS, Bir Hospital, Kathmandu, Nepal.
dc.creator.affiliationGastroenterology Unit, Department of Medicine, NAMS, Bir Hospital, Kathmandu, Nepal.
dc.creator.affiliationGastroenterology Unit, Department of Medicine, NAMS, Bir Hospital, Kathmandu, Nepal.
dc.creator.affiliationGastroenterology Unit, Department of Medicine, NAMS, Bir Hospital, Kathmandu, Nepal.
dc.creator.affiliationGastroenterology Unit, Department of Medicine, NAMS, Bir Hospital, Kathmandu, Nepal.
dc.creator.affiliationGastroenterology Unit, Department of Medicine, NAMS, Bir Hospital, Kathmandu, Nepal.
dc.creator.affiliationInterfaith Medical Center, Brooklyn, NY, USA.
dc.creator.affiliationSure Medical PC, Elmhurst, NY, USA.
dc.creator.affiliationNew York Presbyterian Hospital, Queens, NY, USA.
dc.date.accessioned2026-09-21T05:43:25Z
dc.date.available2026-09-21T05:43:25Z
dc.date.issued2017
dc.description.abstractAbstract Introduction: There are new concepts and developments in the diagnosis and management of acute pancreatitis. Current evidence suggests that there is no role of prophylactic antibiotics use in acute pancreatitis. However, it is still a common practice to administer prophylactic antibiotics in a country like Nepal. So, we have conducted a study in mild and moderately severe acute pancreatitis to study the efficacy of prophylactic antibiotics. Methods: A case control study was conducted among 76 patients comparing efficacy of prophylactic antibiotics versus no antibiotics in patients with mild and moderately severe acute pancreatitis. Results: The two most common etiology of acute pancreatitis in AG and NAG were alcohol 21 (55.2%) vs. 24 (63.1%) and biliary 10 (26.3%) vs. 4 (10.5%) respectively. Pancreatic necrosis was seen in five (13.1 %) in AG and four (10.5%) in NAG. Four (10.5%) developed extra pancreatic complications in AG and five (13.1%) in NAG. There was one (2.6%) death in AG and no death in NAG. Abdominal pain improvement seen in AG vs. NAG was 3.2 days vs. 2.4 days (p =0.002). The hospital stay was 7.7±2.23 days in AG and 7.5±1.85 days in NAG (p=0.65). Conclusions: The routine use of prophylactic antibiotics for mild and moderately severe acute pancreatitis is not associated with improvement in meaningful clinical outcomes. Keywords: Atlanta classification 2012; Mild acute pancreatitis; Moderately severe acute pancreatitis; Prophylactic antibiotic.
dc.identifier.doihttps://doi.org/10.31729/jnma.3130
dc.identifier.urihttps://hdl.handle.net/20.500.14572/7769
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectAtlanta classification 2012
dc.subjectMild acute pancreatitis
dc.subjectModerately severe acute pancreatitis
dc.subjectProphylactic antibiotic
dc.titleEfficacy of prophylactic use of ciprofloxacin and metronidazole in mild and moderately severe acute pancreatitis
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage210
oaire.citation.startPage207
relation.isJournalIssueOfPublication67f4f287-6893-47e1-b45e-2cf1554665ce
relation.isJournalIssueOfPublication.latestForDiscovery67f4f287-6893-47e1-b45e-2cf1554665ce
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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