Publication: Protective Effect of Aqueous Extract of Lagenaria Siceraria (Molina) Against Maximal Electroshock (MES) -Induced Convulsions in Albino Rats
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
The Lagenaria siceraria (Molina) belongs to family Cucurbitaceae, commonly known
as bottle guard or calabash in English. All the parts of plant like root, fruit, leaves and
flower has been evaluated for its various activities like antioxidant, antihelmintic,
cognitive enhancer, anticancer, antianxiety, antidepressant, antihyperlipidemic,
fibrinolytic cardio protective and hepatoprotective. Even though it is claimed to have
antiepileptic action, no documentation is available.
Objective
To assess the anticonvulsant activity of aqueous extract of Lagenaria siceraria by
Maximal Electroshock seizure induced seizure models on Albino rats.
Method
Albino rats were taken and divided into five groups, each consisting of five rats. One
group was used as control (normal saline 10 ml/kg), one as standard (phenytoin),
and three groups for the test drug (aqueous extract of Lagenaria siceraria (AELS) in
the doses of 200, 400 and 800 mg/kg) treatment. In MES model, Maximal electrical
shock of 150 mA was passed for 0.2 seconds through corneal electrodes after 30
minutes of giving the drugs and normal saline. Different stages of convulsions were
noted down along with time spent by the animal in each phase of convulsions. Data
were statistically analyzed by One way ANOVA followed by multiple Dunnett’s test.
Result
The mean reduction in hind limb extension phase was 8.2±2.10 after 400 mg/kg of
AELS which is highly significant (p<0.001) like phenytoin. AELS at 800 mg/kg exhibited
a significant 17±2.64 (p<0.05) protection against tonic extensor phase.
Conclusion
Aqueous extract of Lagenaria siceraria has anticonvulsant activity.
KEY WORDS
Anticonvulsant, epilepsy, lagenaria siceraria, maximal electroshock
Description
Tirumalasetti J,1 Patel MM,2 Shaikh U,1 Pokala N,1 Harini K1
1Department of Pharmacology,
Mamata Medical College,
Khammam -507002
Telangana ,India.
2Department of Pharmacology,
Dr. M. K. Shah Medical College and Research Centre,
Ahmedabad-382424
Gujarat, India
Keywords
Anticonvulsant, epilepsy, lagenaria siceraria, maximal electroshock