Publication: Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study
| creativeworkseries.issn | JNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X | |
| dc.contributor.author | Shah, Naveen Prakash | |
| dc.contributor.author | Regmi, Anil | |
| dc.contributor.author | Acharya, Aakash | |
| dc.contributor.author | K.C., Jwala | |
| dc.contributor.author | Khatiwada, Bidur | |
| dc.contributor.author | Hada, Meera | |
| dc.date.accessioned | 2026-02-12T07:09:01Z | |
| dc.date.available | 2026-02-12T07:09:01Z | |
| dc.date.issued | 2021 | |
| dc.description | Naveen Prakash Shah Department of Pulmonology, National Tuberculosis Control Center, Sanothimi, Bhaktapur, Nepal https://orcid.org/0000-0002-6518-0220 Anil Regmi Department of Pulmonology, National Tuberculosis Control Center, Sanothimi, Bhaktapur, Nepal https://orcid.org/0000-0003-0896-8107 Aakash Acharya Department of Pulmonology, National Tuberculosis Control Center, Sanothimi, Bhaktapur, Nepal https://orcid.org/0000-0002-7759-7883 Jwala K.C. Department of Pulmonology, National Tuberculosis Control Center, Sanothimi, Bhaktapur, Nepal https://orcid.org/0000-0001-9499-1981 Bidur Khatiwada Department of Pulmonology, National Tuberculosis Control Center, Sanothimi, Bhaktapur, Nepal Meera Hada Department of Reference Lab, National Tuberculosis Control Center, Sanothimi, Bhaktapur, Nepal https://orcid.org/0000-0002-8180-1592 | |
| dc.description.abstract | Abstract: Introduction: Sputum non-conversion is smear positive tuberculosis despite anti-tubercular therapy. Various factors may lead to sputum non-conversion including resistance to anti-tubercular drugs, age, gender, disease severity, non-compliance, drugs unavailability etc. Little is known and studied about the contribution of these individual factors. Our study sought to determine the prevalence of sputum smear non-conversion in patients at the end of intensive phase of tuberculosis treatment visiting a tertiary-level institution in Nepal. Methods: A descriptive cross-sectional study was conducted among recorded data of patients undergoing sputum Acid Fast Bacilli staining at the end of intensive phase at National Tuberculosis Control Center from April 2018 to April 2020. The study was approved by Nepal Health Research Council (Registration no: 76012020 P). The convenient sampling method was adopted. The data were analyzed using Microsoft Excel. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Our study found that out of 830 samples that were tested by Acid Fast Bacilli stain at the end of intensive phase, 40 (4.82%) (3.37-6.28 at 95% Confidence Interval) were sputum smear non-converters. The mean age of sputum non-converters was 41.25±15.543 years. Conclusions: The study shows that a significant proportion of patients remain acid-fast stain positive despite the treatment. However, the proportion is low compared to other similar studies around the globe. This study provides program managers with evidence to support the development of more tailored tuberculosis care and need to conduct more intensive studies about various factors that may lead to non-conversion. | |
| dc.identifier | https://doi.org/10.31729/jnma.7020 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/4719 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Medical Association | |
| dc.subject | antitubercular agents | |
| dc.subject | mycobacterium tuberculosis | |
| dc.subject | tuberculosis. | |
| dc.title | Sputum Smear Non-conversion at the End of Intensive Phase of Tuberculosis Treatment at a Tertiary Center: A Descriptive Cross-sectional study | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 1093 | |
| oaire.citation.startPage | 1090 | |
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