Publication: Effect of haemodynamic and metabolic predictors on echocardiographic left ventricular mass in non-diabetic hypertensive patients
Date
2010
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Abstract
Background: Left ventricular hypertrophy is a forerunner of coronary heart disease, congestive cardiac failure, stroke
and may also lead to sudden death. Estimation of left ventricular mass by echocardiography offers prognostic information
better than the evaluation of traditional cardiovascular risk factors.
Objective: The aim of this study was to determine the relative contributions of haemodynamic and metabolic factors
affecting left ventricular mass in non-diabetic patients with essential hypertension.
Material and methods: 100 non-diabetic hypertensive patients were taken. The association between age, gender,
smoking, alcohol, height, weight, heart rate, clinic blood pressure, fasting blood glucose, lipid profile, haemoglobin,
body mass index and stroke volume with LV mass was studied. Left ventricular mass was measured by using standard
M-mode echocardiography measurement obtained by way of standard recommended by the American Society of
Echocardiography.
Results: Left ventricular mass was analyzed as a continuous variable. In males body mass index (r=.35, p<.004) and
stroke volume(r=-.26, p<.039) were significantly correlated with LV mass. In females body weight was significantly
related to left ventricular mass(r=.36, p<.02). The independent association between significant factors and left ventricular
mass was assessed by stepwise multivariate logistic regression. Body mass index and systolic blood pressure came as
independent determinants of left ventricular mass in all patients. A maximum of 13% of left ventricular mass variability
could be explained by these two factors.
Conclusion: In untreated patients with hypertension patient’s body mass index and systolic blood pressure are
independent predictors of left ventricular mass after adjustment for other haemodynamic and metabolic factors. They
explain a maximum of 13% of left ventricular mass variability. More knowledge is needed about factors that may alter
cardiac morphology in the evolution of hypertensive patients.
Key words: Echocardiography, Haemodynamic, Metabolic Factors, Left Ventricular Mass, Non-diabetic, Hypertensive
Description
Gupta N 1, Karki P1 , Sharma S 1 , Shrestha N 1 , Acharya P1
1 Department of Internal Medicine and Cardiology, BP Koirala Institute of Health Sciences, Dharan, Nepal