Publication: Nucleated Red Blood Cell in Cord Blood as a Marker of Perinatal Asphyxia
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Introduction: Perinatal asphyxia is a common problem with the incidence varying from 0.5 –2% of live births. According to World Health Organization, approximately 4 million babies die each year before they reach the age of one month. The number of NRBC/100 WBC is variable but is rarely greater than 10 in normal neonates. This simple test can be helpful in the rapid assessment of perinatal asphyxia.
Material and Methods: This prospective case-control study and there were 82 newborns in Case and 82 newborns in Controls comprising of asphyxiated and nonasphyxiated neonates, respectively, over a period of 12 months.
Results: Out of the 82 neonates in case group, fifty nine (59) neonates were found to have NRBC level ≥10/100WBC, out of which 58 (70.7%) were cases and 1(1.2%) was a control. NRBCs count of ≥10/100WBC were seen more in the newborn who had low 5 min Apgar score and in the newborn with severe HIE, these association were statistically significant (P value <0.001). The cut-off NRBC value of ≥10/100WBC also found to have a sensitivity of 70.30% with a specificity of 98.78%. NRBC has a positive predictive value of 98.31% with a negative predictive value of 77.14%. Significance and sensitive area for ROC curve was 0.875. The ROC curve was calculated with cut-off NRBC value of ≥10/100WBC.
Conclusions: NRBC counts can be very useful to differentiate HIE newborns from non-HIE newborns which will help in appropriate management and better outcome of these newborns.
Description
Piush Kanodia
Department of Paediatrics and Adolescent Medicine, B.P Koirala Institute of Health Sciences, Dharan
Nisha Keshary Bhatta
Department of Paediatrics and Adolescent Medicine, B.P Koirala Institute of Health Sciences, Dharan
Rupa Rajbhandari Singh
Department of Paediatrics and Adolescent Medicine, B.P Koirala Institute of Health Sciences, Dharan
Gauri Shankar Shah
Department of Paediatrics and Adolescent Medicine, B.P Koirala Institute of Health Sciences, Dharan
Shankar Prasad Yadav
Department of Paediatrics and Adolescent Medicine, B.P Koirala Institute of Health Sciences, Dharan
Sunil Kumar Yadav
Department of Paediatrics and Adolescent Medicine, B.P Koirala Institute of Health Sciences, Dharan
Keywords
Apgar score, HIE, NRBC count, Perinatal Asphyxia