Publication: Evaluation of Ischaemia Modified Albumin as a Marker of Oxidative Stress in Beta Thalassemia Major Children
| creativeworkseries.issn | ISSN 1990-7974 eISSN 1990-7982 | |
| dc.contributor.author | Kumar, K Jagadish | |
| dc.contributor.author | Bhagiratha, Smriti | |
| dc.contributor.author | Vishwanath, Prashanth | |
| dc.date.accessioned | 2025-12-12T06:29:53Z | |
| dc.date.available | 2025-12-12T06:29:53Z | |
| dc.date.issued | 2021 | |
| dc.description | K Jagadish Kumar Department of Paediatrics, JSS Medical College, JSS Academy Of Higher Education And Research., Mysore, India Smriti Bhagiratha Department of Paediatrics, JSS Medical College, JSS Academy Of Higher Education And Research., Mysore, India Prashanth Vishwanath Department of Biochemistry, JSS Medical College, JSS Academy Of Higher Education And Research, Mysore, India | |
| dc.description.abstract | Abstract: Introduction: Iron overload in thalassemia catalyses the production of a variety of reactive oxygen species leading to cumulative cell damage. Ischemia modified albumin (IMA) is an end product of oxidative stress. It is imperative to pick up oxidative stress early in order to prevent the organ damage in thalassemia. Therefore this study was undertaken to estimate IMA levels and to see the correlation between ferritin and IMA to establish whether ferritin can be a proxy marker for oxidative stress. Methods: A total of 76 children were included in the study out of which 46 were diagnosed cases of β- Thalassemia major and 30 formed the healthy controls. Pre transfusion haemoglobin, AST, ALT, ferritin and IMA levels were estimated and compared with healthy control children. Correlation was drawn between haemoglobin, AST, ALT, ferritin with IMA. Results: There is significant elevation in the level of IMA and ferritin in children with Thalassemia major as compared to the healthy controls (p = < 0.001). There was a significant positive correlation between ferritin and IMA and a significant negative correlation between haemoglobin % and IMA. Regression relationship between ferritin and IMA established that IMA (ng/ mL) = 246.118 + 0.829 (Ferritin ng/dL). Conclusions: IMA levels were significantly elevated in β- thalassemia major children and correlated positively with ferritin levels. By establishing a regression relationship between ferritin and IMA levels, we can fairly estimate the levels of IMA. Hence, we can utilise ferritin as a proxy marker of oxidative stress instead of IMA. | |
| dc.identifier | https://doi.org/10.3126/jnps.v41i1.29931 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/3586 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Paediatric Society (JNPS) | |
| dc.subject | β-thalassemia major | |
| dc.subject | Ferritin | |
| dc.subject | Ischemia modified albumin (IMA) | |
| dc.subject | Oxidative stress | |
| dc.title | Evaluation of Ischaemia Modified Albumin as a Marker of Oxidative Stress in Beta Thalassemia Major Children | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 66 | |
| oaire.citation.startPage | 61 | |
| relation.isJournalIssueOfPublication | 6de7ba9f-9cce-481b-ab42-d3a1b3a0deab | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 6de7ba9f-9cce-481b-ab42-d3a1b3a0deab | |
| relation.isJournalOfPublication | 6f9be05c-05a9-4a3e-a5b5-a19a15ab042c |