Article:
Extensive mucosal erosion and sloughing of tongue: a hitherto unknown complication of topical clotrimazole preparation

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorDutta, Mainak
dc.contributor.authorGhatak, Soumya
dc.contributor.authorBiswas, Gautam
dc.contributor.authorSinha, Ramanuj
dc.creator.affiliationDepartment of Otorhinolaryngology and Head-Neck Surgery, Medical College and Hospital, Kolkata, West Bengal, India.
dc.creator.affiliationDepartment of Otorhinolaryngology and Head-Neck Surgery, R. G. Kar Medical College and Hospital, Khudiram Bose Sarani, Kolkata, West Bengal, India.
dc.creator.affiliationDepartment of Otorhinolaryngology and Head-Neck Surgery, Murshidabad Medical College and Hospital, Berhampore, Murshidabad, West Bengal, India.
dc.creator.affiliationDepartment of Otorhinolaryngology and Head-Neck Surgery, R. G. Kar Medical College and Hospital, Khudiram Bose Sarani, Kolkata, West Bengal, India.
dc.date.accessioned2026-10-30T09:05:40Z
dc.date.available2026-10-30T09:05:40Z
dc.date.issued2013
dc.description.abstractAbstract Clotrimazole, a broad-spectrum imidazole antimycotic, is a widely-used prescription as well as an over-the-counter drug for treatment of mucosal (oral, vulvovaginal) candidiasis and dermatophytes. An extremely safe and well-tolerated drug, its safety profile has been well-explored in researches and trials. The commonest complaints are almost always non-serious-pruritus, rashes, paraesthesia (stinging/burning sensation) and erythema on topical applications, and nausea, vomiting, unpleasant taste sensation and elevated liver enzymes on oral preparations (troches). However, mucosal ulceration on topical clotrimazole preparation has not been reported in literature before. We present here the first documentation of extensive bilateral erosions and necrosis of tongue involving the mucosa, submucosa and musculature on application of one percent weight/volume clotrimazole mouth paint in a 27-year-old immunocompetent woman who presented with oral candidiasis. Keywords: Extensive bilateral ulceration and necrosis; Oral candidiasis; Side effect; Topical clotrimazole.
dc.identifier.doihttps://doi.org/10.31729/jnma.585
dc.identifier.urihttps://hdl.handle.net/20.500.14572/8265
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectExtensive bilateral ulceration and necrosis
dc.subjectOral candidiasis
dc.subjectSide effect
dc.subjectTopical clotrimazole
dc.titleExtensive mucosal erosion and sloughing of tongue: a hitherto unknown complication of topical clotrimazole preparation
dc.typeArticle
dspace.entity.typePublication
local.article.typeCase Report
oaire.citation.endPage280
oaire.citation.startPage277
relation.isJournalIssueOfPublication507851c9-2e6f-426d-a5b1-31d82e76b215
relation.isJournalIssueOfPublication.latestForDiscovery507851c9-2e6f-426d-a5b1-31d82e76b215
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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