Outcome of Improvised Bubble Continuous Positive Airway Pressure (bCPAP) in Respiratory Distress Syndrome (RDS) and Factors Associated with its Failure: A Prospective Observational Study

Basnet, Srijana; Aryal, Surabhi; Poudel, Daman Raj; Shrestha, Laxman

Publication:
Outcome of Improvised Bubble Continuous Positive Airway Pressure (bCPAP) in Respiratory Distress Syndrome (RDS) and Factors Associated with its Failure: A Prospective Observational Study

creativeworkseries.issn	ISSN 1990-7974 eISSN 1990-7982
dc.contributor.author	Basnet, Srijana
dc.contributor.author	Aryal, Surabhi
dc.contributor.author	Poudel, Daman Raj
dc.contributor.author	Shrestha, Laxman
dc.date.accessioned	2025-10-29T10:17:16Z
dc.date.available	2025-10-29T10:17:16Z
dc.date.issued	2023
dc.description	Srijana Basnet Associate Professor, Department of Paediatrics, Institute of Medicine (IOM), Maharajgunj, Kathmandu, Nepal Surabhi Aryal Assistant Professor, Department of Paediatrics, Institute of Medicine (IOM), Maharajgunj, Kathmandu, Nepal Daman Raj Poudel Assistant Professor, Department of Paediatrics, Institute of Medicine (IOM), Maharajgunj, Kathmandu, Nepal Laxman Shrestha Professor, Department of Paediatrics, Institute of Medicine (IOM), Maharajgunj, Kathmandu, Nepal
dc.description.abstract	Abstract: Introduction: Bubble CPAP (bCPAP) is the standard treatment for newborn with RDS but is challenged by availability of proper bCPAP delivery devices. The improvised bCPAP using modified nasal prong with expiratory limb immersed in water is commonly used to deliver pressurized air to the neonate’s lungs. The primary objective of the study was to evaluate effectiveness of improvised bCPAP in treating Respiratory distress syndrome (RDS) and to identify factors that may be associated with its failure. Methods: In this prospective observational study, all consecutively born preterm neonates delivered before 37 weeks of gestation, admitted to the neonatal intensive care unit (NICU) with diagnosis of RDS and needed bCPAP were included in the study. Early rescue surfactant was given according to NICU protocol of the hospital. Those neonates failed to improve despite treatment with Continuous Positive Airway Pressure (CPAP) and needed MV within 96 hours of life are considered as CPAP failure (CPAP-F). Results: 119 preterm newborn with mean gestational age was 31.95 ± 2.05 weeks and birth weight 1614.33 ± 454.32 gm were enrolled. bCPAP was successful in 22 (18.5%) preterm infants. The mean duration of Continuous Positive Airway Pressure (CPAP) was 61.21 ± 41.81 hours and NICU stay was 12.34 ± 8.12 days. Surfactant was given in 51 (42.9%) and mortality rate was 17 (14.29%). Multivariable logistic regression analysis showed gestational age less than 32 weeks 0.534 (95%CI: 0.340-0.839) and pneumothorax 22 (95%CI: 2.122 - 228.070) are independent risk factors associated with CPAP-F. Conclusions: Improvised bCPAP is effective in the management of respiratory distress syndrome (RDS). Pneumothorax and gestational age < 32 weeks are independent risk factor for its failure.
dc.identifier	https://doi.org/10.60086/jnps547
dc.identifier.uri	https://hdl.handle.net/20.500.14572/2892
dc.language.iso	en_US
dc.publisher	Nepal Paediatric Society (JNPS)
dc.subject	CPAP
dc.subject	preterm
dc.subject	RDS
dc.subject	Surfactant
dc.title	Outcome of Improvised Bubble Continuous Positive Airway Pressure (bCPAP) in Respiratory Distress Syndrome (RDS) and Factors Associated with its Failure: A Prospective Observational Study
dc.type	Article
dspace.entity.type	Publication
local.article.type	Original Article
oaire.citation.endPage	163
oaire.citation.startPage	156
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