Publication: Correlation of PAP smear findings with clinical findings and cervical biopsy
Date
2007
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Abstract
Objectives: Carcinoma of the cervix is the most common cause of the death in Nepal. Cervical carcinoma does not
develop suddenly from normal epithelium but is presented by a spectrum of intraepithelial neoplastic changes that
are precancerous lesion and were termed as cervical intraepithelial neoplasia (CIN). Cervical cytological screening
is designed to detect over 90% of cytological abnormalities. It has also been established that most cervical cancers
can be diagnosed at the preinvasive stage with adequate and repetitive cytological screening. Keeping in view of the
importance of carcinoma and the precancerous lesion (CIN) of cervix, study of different methods for the early
detection of abnormalities in cervix, correlation with the clinical findings and comparison between the techniques
was carried out.
Material and methods: Patients with suspicious cervix attending Gynaecology OPD of TUTH and Western
regional hospital (Pokhara) who have undergone for pap smear cytology test along with biopsy were selected. Detail
history with clinical examination was performed and the findings were correlated.
Results and conclusion: Unhealthy cervix with discharge was found to be common even in chronic cervicitis
however bleeding and tenderness were associated with more advanced lesions. Pap smear test was found to be
equally sensitive to histopathological examination for the early detection of different cervical lesions. However, it is
advised to perform biopsy if any abnormalities are detected in pap smear for correlation and confirmation.
Key words: Pap smear, CIN
Description
B Pradhan
Lecturer, Department of Community Medicine
SB Pradhan
Lecturer, Department of Pathology
VP Mital
Professor and Head, Department of Pathology, Kathmandu Medical College & Teaching Hospital, Sinamangal, Kathmandu, Nepal