Publication: Peripheral Airway Responsiveness to Sub-maximal Exercise in Asymptomatic Cigarette Smokers
Date
2011
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Cigarette smoking is one of the cardinal causes for the development of bronchial
hyperresponsiveness among the smokers.
Objectives
This study was perspectively designed to determine the peripheral bronchial
responsiveness to sub-maximal exercise challenge in the asymptomatic smokers.
Methods
The subjects were between age of 18-25 years without any findings of cardio-
respiratory diseases. We performed the 5 min step test exercise at intensity of 80 to
90% of maximum predicted heart rate in 42 young adult male asymptomatic smokers
to examine the effect of cigarette smoking on airway responsiveness. Forced expiratory
spirogram was recorded before and at 0, 5, 10, 15 min after the completion of exercise.
Pre- to post exercise drop in Forced Expiratory Volume in first second ≥ 15% was
considered hyperresponsive to the challenge.
Result
The analysis of data (mean± SE) indicated the bronchial hyper-responsiveness in
22 (52%) smokers. The post exercise recovery time pattern showed drop in forced
expiratory spirogram from the resting baseline in the responsive smokers and the
maximum percentage fall in the parameters or increase in airway resistance which
reflect the peripheral airway integrity such as Forced Expiratory Flow 25% (20.30
±2.18 Vs 7.88 ±3.23, p<0.01), Forced Expiratory Flow 50% (18.46 ±4.40 Vs 1.93 ±2.78,
p<0.01), Forced Expiratory Flow 75% (23.94 ±3.68 Vs 0.80 ±4.72, p<0.001) and Forced
Expiratory Flow 25-75% (32.50 ±4.79 Vs 3.64 ±3.32, p<0.001) was significantly higher in
the responsive than non-responsive subgroup of the smokers.
Conclusion
The occurrence of peripheral airway resistance is more in the responsive than non-
responsive subset of smokers to the exercise challenge and hence more prone to
develop obstructive airway disease in the long run.
KEY WORDS
airway hyper-responsiveness, cigarette smokers, forced expiratory flow
Description
Pokhrel BR,1 Chatopadhyaya S,2 Paudel BH.3
1Department of Physiology Kathmandu Univerisity School of Medical Sciences Dhulikhel, Nepal
2Department of Physiology Kalinga Institute of Medical Sciences Orrisa, India
3Department of Physiology BPKIHS Dharan, Nepal.