Publication: Drug induced hepatitis with anti-tubercular chemotherapy: Challenges and difficulties in treatment
Date
2007
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Tuberculosis is a major health burden worldwide. In Nepal, it is a significant cause of morbidity and mortality.
Although better drugs are available for managing tuberculosis, treatment failure is one of the common problems
encountered. Among the various causes which can cause treatment interruption, drug induced hepatotoxicity is a
common cause. Isoniazid and Pyrazinamide are the common drugs causing hepatotoxicity. Upon occurrence of
hepatotoxicity, the hepatotoxic drugs should be stopped and reintroduced as per the available guidelines. The
healthcare professional should also counsel the patients for recognizing the early symptoms due to hepatotoxicity
which could prevent morbidity.
Key words: Adverse effects, Hepatotoxicity, Tuberculosis.
Description
Kishore PV 1, Palaian S 2, Paudel R 3 , Mishra P4, Prabhu M 5, Shankar PR 6
1,6 Assitant Professors, 2,3 Lecturer, 4,5 Associate Professors, Manipal Teaching Hospital / Manipal College of Medical Sciences, Pokhara, Nepal