Publication: Chronic Spontaneous Urticaria: Clinical Profile, Autologous Serum Skin Test Positivity and Associated Impairment in Quality of Life in Nepalese Patients
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Chronic Spontaneous Urticaria is considered to be an autoimmune phenomenon in
half of the total cases. Autologous serum skin test is a simple screening test for the
presence of auto-antibodies in chronic urticaria. Significant impairment in quality
of life have been observed in autologous serum skin test positive cases. There are
limited literatures on chronic spontaneous urticaria, autologous serum skin test and
associated Dermatology Life Quality Index in Nepal till date.
Objective
To find the proportion of autologous serum skin test positive cases in chronic urticaria
and impairment in quality of life in such patients.
Method
This was a retrospective review of outpatient records of patients diagnosed with
chronic spontaneous urticaria, from January 2018 to December 2019, from a tertiary
care hospital in Kathmandu, Nepal. Details of the patients, autologous serum skin
test and dermatology life quality index scores were analyzed and presented.
Result
Among the total 114 cases positive autologous serum skin test was seen in 48.2%
of cases. The mean total Dermatology Life Quality Index score was 8.06±6.64. A
significantly higher quality of life impairment was observed in in patients with
positive autologous serum skin test as compared to the negative ones. The odds of
finding a positive autologous serum skin test in patients with angioedema was 2.1,
however the difference was not statistically significant.
Conclusion
Chronic spontaneous urticaria was more common in females as compared to males.
A positive autologous serum skin test was present in half of the patients which was
in turn associated with a greater impairment of quality of life.
KEY WORDS
Autologous serum skin test, Chronic urticaria, Dermatology life quality index, Quality
of life
Description
Paudel S,1 Parajuli N,2 Sharma R,1 Parajuli S3
1Civil Service Hospital
2National Academy of Medical Sciences
3Tribhuvan University Teaching Hospital
Institute of Medicine, Kathmandu, Nepal
Keywords
Autologous serum skin test, Chronic urticaria, Dermatology life quality index, Quality of life