Publication: Recurrent Positivity of SARS-CoV-2 RNA in a Clinically Recovered COVID-19 Patient with End Stage Renal Disease: A Case Report
Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract:
Recurrent or persistent positivity of SARS-CoV-2 RNA in clinically recovered COVID-19 patients have been reported worldwide. However, replication competent live viruses were not recovered beyond two to three weeks from onset of symptoms in mild to severe cases of COVID-19. End stage renal disease is characterized by uremia induced immune dysfunction that increases the risk of infectious diseases including COVID-19. The clinical implications of recurrent or persistently positive SARS-CoV-2 RNA in immunocompromised patients are difficult to be generalized to findings as in immunocompetent patients. We report a case of end stage renal disease with recent history of recovered COVID-19 pneumonia, who again presented with positive reverse transcriptase- polymerase chain reaction (RT-PCR) test for SARS-CoV-2 RNA.
Description
Richa Nepal
Department of Internal Medicine, Bharatpur Hospital, Bharatpur, Province-3, Chitwan, Nepal
https://orcid.org/0000-0001-7576-2593
Kalyan Sapkota
Department of Internal Medicine, Bharatpur Hospital, Bharatpur, Province-3, Chitwan, Nepal
https://orcid.org/0000-0003-4011-6430
Santosh Gurung
Department of Internal Medicine, Bharatpur Hospital, Bharatpur, Province-3, Chitwan, Nepal
https://orcid.org/0000-0002-1069-8030
Pramod Paudel
Department of Internal Medicine, Bharatpur Hospital, Bharatpur, Province-3, Chitwan, Nepal
Prateek Neupane
Department of Internal Medicine, Bharatpur Hospital, Bharatpur, Province-3, Chitwan, Nepal
Kamlesh Kumar Sah
Department of Internal Medicine, Bharatpur Hospital, Bharatpur, Province-3, Chitwan, Nepal
Keywords
coronavirus disease, COVID-19, end-stage kidney disease, severe acute respiratory syndrome coronavirus-2