Publication: Gene-environment Interaction: The Causes of High Obesity Incidence
Date
2017
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Urbanization has provided experimental settings for testing the interactive
relationship between genetic background and changes in lifestyle and dietary
patterns. The concept of gene-environment interaction was described by epidemic
of obesity along with urbanization. Genome-wide association has identified
several genes such as melanocortin-4 receptor that associates with environmental
influences of obesity. Gene environment (GxE) interaction refers to modification
by an environmental factor of the effect of a genetic variant on a phenotypic trait.
GxE interactions can serve to modulate the adverse effects of a risk allele, or can
exacerbate the genotype-phenotype relationship and increase risk.
KEY WORDS
Environmental factors, gene-environment interaction, genetic predisposition,
obesity, social networks
Description
Mohammed S. Ellulu,1 Marwan O. Jalambo2
1Clinical Nutrition Specialist
Gaza, Palestine
2Faculty of Health Sciences, University Kebangsaan
Malaysia (UKM), Malaysia
Keywords
Environmental factors, gene-environment interaction, genetic predisposition, obesity, social networks