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High Sensitive C-Reactive Protein and Lipid Profile Alteration In Subclinical Hypothyroidism for Cardiovascular Risk Assessment

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creativeworkseries.issn1999-6217
dc.contributor.authorRajkarnikar, Smrity
dc.contributor.authorSharma, Vijay Kumar
dc.contributor.authorBaidya, Sujata
dc.contributor.authorKadel, Pratibha
dc.contributor.authorTuladhar, Eans Tara
dc.contributor.authorNiraula, Apeksha
dc.contributor.authorBhattarai, Aseem
dc.contributor.authorRaut, Mithileshwer
dc.contributor.authorDubey, Raju Kumar
dc.contributor.authorParajuli, Naresh
dc.date.accessioned2025-07-18T05:06:51Z
dc.date.available2025-07-18T05:06:51Z
dc.date.issued2024
dc.descriptionSmrity Rajkarnikar Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Vijay Kumar Sharma Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Sujata Baidya Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Pratibha Kadel Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Eans Tara Tuladhar Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Apeksha Niraula Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Aseem Bhattarai Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Mithileshwer Raut Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Raju Kumar Dubey Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Naresh Parajuli Department of Internal Medicine (Endocrinology), Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
dc.description.abstractBackground: The purpose of this study was to investigate the association of subclinical hypothyroidism with High sensitive C-reactive protein & lipid profile which can predispose to development of Cardiovascular disease. Methods: This hospital-based comparative cross-sectional study was conducted for a period of six months. A total of 71 patients with subclinical hypothyroidism & 37 healthy control subjects were enrolled for the study. Thyroid hormones, lipid profile, hs- CRP were measured and lipid variables were used to calculate lipid indices. Student t-test were used to compare means & Spearman’s correlation was done to determine the association between variables. ROC curve analysis was used to determine the diagnostic value of tests. Results: Out of 71 cases & 37 control, majority had female preponderance (71.8% in case & 83.8% in control). The mean values between case & control groups for hs-CRP, AIP, LCI and non-HDL cholesterol were statistically significant. There was positive correlation between TSH and hs-CRP (r=0.492, p <0.001), AIP and TSH (r=0.430, p<0.001), LCI and TSH (r=0.269, p =0.005), TSH and non-HDL cholesterol (r=0.308, p=0.001) & AI and LDL (r= 0.712, p<0.001) with weak correlation with statistical significance as per Spearman’s correlation. Area under ROC curve for hs-CRP indicated it as a positive biomarker for CVD assessment. Conclusions: Our findings shows that SCH patients are more at risk of CVD & hs-CRP contributes as a significant marker, thus requiring timely intervention. Lipid indices and AIP must be determined even in patients with a normal lipid profile to improve atherogenic risk. Keywords: Cardiovascular risk; dyslipidemia; hs-CRP; subclinical hypothyroidism.
dc.identifierhttps://doi.org/10.33314/jnhrc.v22i02.5383
dc.identifier.urihttps://hdl.handle.net/20.500.14572/346
dc.language.isoen_US
dc.publisherNepal Health Research Council
dc.titleHigh Sensitive C-Reactive Protein and Lipid Profile Alteration In Subclinical Hypothyroidism for Cardiovascular Risk Assessment
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage310
oaire.citation.startPage306
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relation.isJournalIssueOfPublication.latestForDiscoverye2d42a19-cf81-48dd-bb3c-195f14182d84
relation.isJournalOfPublication40bd2739-8b19-447c-be60-723a1bdd1dcd

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