Publication: Evaluation of anxiolytic activity of tensarin in mice
Date
2007
Authors
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Publisher
Kathmandu University
Abstract
Introduction: Anxiolytic drugs are amongst the most frequently prescribed drugs. Available anxiolytic agents are
associated with several limitations. Several indigenous drugs are being evaluated but none has been proved to be
effective.
Objectives: Aim of the present study is to evaluate the anxiolytic effect of Tensarin.
Material and method: The behavioural tests were conducted with single dose schedule and multiple seven-dose
schedules of Tensarin 50mg/kg, 100mg/kg and 200mg/kg in comparison with Diazepam 1mg/kg in mice using open
field test, activity-monitoring and passive avoidance test. There were eight treatment groups in each treatment
schedule. Each group consisted of ten animals of either sex. The data obtained were analyzed using non- parametric
test and P-value of less than 0.05 was considered to be statistically significant.
Results: Multiple doses produced anxiolytic effect as indicated by an increase in rearing, number of crossing and
the time spent by the animals in Central Square. It was also seen that there was significant decrease in step down
latency, increase in step down error and time spent by animal in shock zone, these effects were not observed in
single dose study.
Conclusion: Tensarin shows a dose dependent anxiolytic effect but further studies are needed to find out the exact
mechanism of action of the formulation.
Key words: Tensarin, Anxiolytic activity, Open field test, Passive avoidance test.
Description
Rauniar GP1 , Deo S 2, Bhattacharya SK 3
1Additional Professor 2 PG student 3Professor and Head, Department of Pharmacology, BP Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal