Publication: Globozoospermia
Date
2023
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Male infertility may be due to low sperm concentration, poor sperm motility, or
abnormal morphology. Among the factors involved in male infertility, there is a
rare morphology disorder called “Globozoospermia”. This condition is primarily
characterized by the presence of round-headed spermatozoa, absence of acrosomal
cap and cytoskeleton defects around the nucleus. The morphological characteristics
of globozoospermia are formed during spermiogenesis. We report here a case of
male infertility due to morphological disorder Globozoospermia. Assessment of
semen by observing macroscopic and microscopic parameters are not sufficient
for sperm analysis. In present case, macroscopic and microscopic assessment was
within normal range. Morphological assessment showed 80% of spermatozoa
with round head and absence of acrosomal cap. The absence of acrosome makes
fertilization impossible since these sperm are unable to bind to the zona pellucida.
By using Intracytoplasmic Sperm Injection (ICSI), conception is possible; however,
the fertilization rate remains very low.
KEY WORDS
Globozoospermia, Male infertility, Morphology
Description
Bhattarai L,1 Gautam B,2 Raut BB,2 Chettri S2
1Department of Anatomy
Universal College of Medical Sciences, Bhairahawa, Nepal
2Department of Gynaecology
Lumbini Province Hospital, Butwal, Nepal
Keywords
Globozoospermia, Male infertility, Morphology