Publication: Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study
| creativeworkseries.issn | JNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X | |
| dc.contributor.author | Tuladhar, Lujaw Ratna | |
| dc.contributor.author | Shrestha, Shirish Lal | |
| dc.contributor.author | Bimali, Sneha | |
| dc.contributor.author | Bhusal, Srijana | |
| dc.contributor.author | Khadka, Pingala | |
| dc.date.accessioned | 2026-02-12T08:32:17Z | |
| dc.date.available | 2026-02-12T08:32:17Z | |
| dc.date.issued | 2021 | |
| dc.description | Lujaw Ratna Tuladhar Department of Pharmacology, Nepal Medical College and Teaching Hospital, Kathmandu, Nepal https://orcid.org/0000-0002-1626-1104 Shirish Lal Shrestha Department of Medicine, Nepal Medical College and Teaching Hospital, Kathmandu, Nepal https://orcid.org/0000-0003-1734-5649 Sneha Bimali Nepal Medical College and Teaching Hospital, Kathmandu, Nepal https://orcid.org/0000-0003-4137-1767 Srijana Bhusal Nepal Medical College and Teaching Hospital, Kathmandu, Nepal https://orcid.org/0000-0001-7476-2567 Pingala Khadka Nepal Medical College and Teaching Hospital, Kathmandu, Nepal https://orcid.org/0000-0003-3640-742X | |
| dc.description.abstract | Abstract: Introduction: Drug-drug interaction is one of the causes of adverse drug reactions. Generally, drug-drug interaction is common in multidrug therapy. Diabetic patients, particularly due to associated comorbidities tend to have various drug-drug interactions due to the effect of multiple drugs. The objective of this study was to find out the prevalence of drug-drug interactions in diabetic patients. Methods: It was a descriptive cross-sectional study that was conducted among previously diagnosed diabetic patients visiting the outpatient department of medicine at a tertiary care hospital between March 2021 and August 2021. Ethical approval was taken from the institutional review committee (Ref no: 030-076/077). Data was collected from diabetic patients presenting to the outpatient department of medicine using a preformed self-constructed questionnaire. Convenient sampling was done. Statistical Package for Social Sciences version 21 and Microsoft Excel were used for data analysis. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: The prevalence of drug-drug interaction between hypoglycemic and non-hypoglycemic medication was 56 (44.1%) (35.5-52.7 at 95% Confidence Interval) of the patients out of which at least one drug-drug interaction was seen in 48 (37.8%) of the patients. Conclusions: Our study showed the prevalence of drug-drug interactions in diabetic patients to be higher than other studies done in similar settings. Based on the severity, we observed two types of drug-drug interactions; close monitoring drug-drug interactions and minor drug-drug interactions. | |
| dc.identifier | https://doi.org/10.31729/jnma.7080 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/4727 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Medical Association | |
| dc.subject | diabetes mellitus | |
| dc.subject | drug interactions | |
| dc.subject | hypoglycemic agents. | |
| dc.title | Drug-drug Interactions between Hypoglycemic and Non-hypoglycemic Medication in Diabetic Patients with Comorbidities in a Tertiary Care Center: A Descriptive Cross-sectional Study | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 1130 | |
| oaire.citation.startPage | 1125 | |
| relation.isJournalIssueOfPublication | 845ac967-f06a-4939-8311-7a30cb7c0f0a | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 845ac967-f06a-4939-8311-7a30cb7c0f0a | |
| relation.isJournalOfPublication | e6e146a0-0ece-4aba-aa0a-6ccfbd10a12a |