Publication: Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management
| creativeworkseries.issn | 1999-6217 | |
| dc.contributor.author | Shrestha, Rohit | |
| dc.contributor.author | Tamrakar, Sudichhya | |
| dc.contributor.author | Koju, Pramesh | |
| dc.contributor.author | Maharjan, Sagar | |
| dc.contributor.author | Malla, Subhechhya | |
| dc.contributor.author | Shrestha, Sony Shakya | |
| dc.date.accessioned | 2025-08-05T11:12:00Z | |
| dc.date.available | 2025-08-05T11:12:00Z | |
| dc.date.issued | 2022 | |
| dc.description | Rohit Shrestha Department of Orthopedics, Dhulikhel Hospital- Kathmandu University Hospital Sudichhya Tamrakar Research and Development Division, Dhulikhel Hospital, Dhulikhel, Nepal Pramesh Koju Pharmacovigilance Unit, Dhulikhel Hospital, Dhulikhel, Nepal Sagar Maharjan Department of Orthopedics, Dhulikhel Hospital- Kathmandu University Hospital Subhechhya Malla Department of Physiotherapy, Dhulikhel Hospital- Kathmandu University Hospital Sony Shakya Shrestha Department of Pharmacology, Kathmandu University School of Medical Sciences, Kathmandu University, Dhulikhel, Nepal | |
| dc.description.abstract | Abstract Background: Designated as a “priority disease” by World Health Organization, Osteoarthritis is the most common chronic rheumatic disease. Providing a proper treatment for Osteoarthritis is still a major public health challenge. Diacerein has been proposed as a slow acting, symptom modifying or even disease modifying drug used in Osteoarthritis having a risk-benefit ratio far better than conventionally used drugs. However, the evidence of efficacy and safety of use of Diacerein in Osteoarthritis is yet to be explored. Hence, this study attempted to investigate the efficacy and safety of Diacerein in the management of knee osteoarthritis. Methods: This is an analytical cohort study comparing Diacerein with Non-steroidal anti-inflammatory drugs for two months in the management of knee OA. Efficacy was assessed by scores of Lysholm Knee Scoring Scale, Knee injury and Osteoarthritis Outcome Score – Physical Function Short form and Western Ontario and McMaster Universities Osteoarthritis Index. Results: After two months of treatment, the post- treatment scores were significantly superior to the baseline scores in both the treatment groups (p<0.001). There were no significant differences among the post-treatment scores in two different treatment groups (p>0.05). Discoloration of urine and gastritis were the frequently reported adverse effects in Diacerein treatment group and Non-steroidal anti-inflammatory drugs treatment group respectively. Conclusions: Our findings have shown Diacerein is as effective as Non-steroidal anti-inflammatory drugs in treating knee OA patients. Diacerein was generally well tolerated, with a good safety profile. These findings indicate the need for further studies with experimental study design in larger scale. Keywords: Diacerein; Efficacy; Knee Osteoarthritis; NSAIDs; Safety | |
| dc.identifier | https://doi.org/10.33314/jnhrc.v20i4.4323 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/1286 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Health Research Council | |
| dc.title | Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 946 | |
| oaire.citation.startPage | 942 | |
| relation.isJournalIssueOfPublication | bab336f9-a344-4947-87ff-8532a3808cc5 | |
| relation.isJournalIssueOfPublication.latestForDiscovery | bab336f9-a344-4947-87ff-8532a3808cc5 | |
| relation.isJournalOfPublication | 40bd2739-8b19-447c-be60-723a1bdd1dcd |