Article: Gefi tinib monotherapy in advanced non-small-cell lung cancer: a retrospective analysis
| creativeworkseries.issn | JNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X | |
| dc.contributor.author | Shrestha, S | |
| dc.contributor.author | Joshi, P | |
| dc.creator.affiliation | Om cancer Care Center, Om hospital and Research Center, Chabahil, Kathmandu, Nepal. | |
| dc.creator.affiliation | Om cancer Care Center, Om hospital and Research Center, Chabahil, Kathmandu, Nepal. | |
| dc.date.accessioned | 2026-11-04T05:56:32Z | |
| dc.date.available | 2026-11-04T05:56:32Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Abstract Introduction: There is no published data in Nepal regarding the use of gefi tinib in patients with non-small cell lung cancer (NSCLC). Therefore, a retrospective analysis was conducted to evaluate the response and toxicity profi le of Gefi tinib alone in patients with advanced NSCLC and unknown epidermal growth factor receptor (EGFR) status. Methods: A single institutional retrospective study was conducted for the period from January 2004 to December 2006 involving patients with locally advanced or metastatic NSCLC who received gefi tinib as monotherapy Primary objective was to evaluate the objective tumor response rate. Results: A total of 36 patients with advanced NSCLC who received gefi tinib 250 mg orally once daily as 1st, 2nd, 3rd, and 4th line treatment in 7, 14, 9, and 6 patients respectively were included in the analysis. Comparable number of patients pertaining to sex, smoking status, and tumor histology were included. The overall response rate at 3 months was 60% including 47% in males and 68% in females. After one month 38% and 6.6% patients with adenocarcinoma and squamous histology respectively responded to gefi tinib therapy. The median progression-free survival was 5.7 months. Toxicities were generally mild with diarrhea, rash and pruritus being the most commonly observed side effects. Conclusion: In this single-center experience, gefi tinib demonstrated clinically signifi cant response in overall population and provided good palliation in pretreated patients. Keywords: Advanced stage NSCLCs, EGFR-TKIs, Gefitinib, Monotherapy, Nepal. | |
| dc.identifier.doi | https://doi.org/10.31729/jnma.71 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/8316 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Medical Association | |
| dc.subject | Advanced stage NSCLCs | |
| dc.subject | EGFR-TKIs | |
| dc.subject | Gefitinib | |
| dc.subject | Monotherapy | |
| dc.subject | Nepal | |
| dc.title | Gefi tinib monotherapy in advanced non-small-cell lung cancer: a retrospective analysis | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 71 | |
| oaire.citation.startPage | 66 | |
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