Publication: Triiodothyronin, Thyroxine and Thyrotropin in Vitiligo
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Vitiligo is a common pigmentary disorder of the skin, affecting individuals globally.
Not only is this ailment psychologically incapacitating, it also has a high incidence of
autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of
immune system.
Objective
The aim of this study is to find out the situations of abnormal thyroid function test (TFT)
in vitiligo patients.
Methods
A prospective cross sectional study was conducted at the Dhulikhel Hospital, KUTH,
Dhulikhel during November 2008 to January 2011 with the objective to assess the
thyroid function tests in vitiligo patients.
Results
Total 66 vitiligo patients with male 30 (45%) and female 36 (55%). Total 26 (39.39%)
vitiligo patients have been found to have abnormal thyroid function test. Among them
10 had abnormal T3, seven had abnormal T4 and 12 had abnormal TSH level. Thyroid
function test were normal in other vitiligo patients. Total seven vitiligo had high level of
T3 than normal value, four male and three female. Two had higher level of T4 above 2.0
ng/dl and all were male, while five had abnormally low level of T4 with three male and
two female. There were seven vitiligo patient with increased T3 level and three with
decreased T3 level, among them six were males and four were females, the age group
was ranged from seven to 68 years old. The T4 level were found abnormal in seven
vitiligo patients among which five were males and two were females with the age group
ranging from 7 to 51 years.
Conclusions
There has been significant association of thyroid disorder in the patient with vitiligo.
Therefore, patient with vitiligo need to undergo thyroid function test to rule out the
thyroid disorder and prevent from long-term complications.
KEYWORDS
thyroid, thyroxin, thyroid function test, vitiligo
Description
Subba K,1 Karn D,2 Khatri R3
1B&B Hospital, Gwarko, Lalitpur.
2Department of Dermatology and Venereology Kathmandu University School of Medical Sciences – Dhulikhel Hospital, Kavre, Nepal
3Patan Academy of Health Sciences, Patan, Lalitpur