Publication: Tearfilm immunoglobulin E (IgE) level in vernal keratoconjunctivitis by ELISA
| creativeworkseries.issn | 1812-2027 | |
| dc.contributor.author | Pokharel, S | |
| dc.contributor.author | Shah, DN | |
| dc.contributor.author | Joshi, SN | |
| dc.contributor.author | Choudhary, M | |
| dc.date.accessioned | 2025-08-05T05:35:49Z | |
| dc.date.available | 2025-08-05T05:35:49Z | |
| dc.date.issued | 2009 | |
| dc.description | Pokharel S1, Shah DN 2, Joshi SN 3, Choudhary M 4 1 Lecturer, Ophthalmology Department, Kathmandu Medical College, Sinamangal, 2 Professor, 3 Associate Professor, 4 Lecturer, Ophthalmology Department, Institute of Medicine, Maharajgunj, Nepal. | |
| dc.description.abstract | Abstract Background: Vernal keratoconjunctivitis (VKC) is recurrent chronic allergic conjunctivitis occurring in the prepubertal age-group with secondary involvement of the cornea and is self-limiting in character. The disease is prevalent world- wide but it shows predominance in the areas with dry and warm climate including the South Asia. VKC represents about 3% of the serious ophthalmic disease in some parts of the world where the prevalence is rate is high.Type I hypersensitivity reaction which is IgE-dependent and type IV hypersensitivity reaction have been implicated for the pathogenesis VKC. Objective: To determine level of immunoglobulin E (IgE) in the tear film of patients with Vernal Keratoconjunctivitis (VKC) attending outpatient department of BP Koirala Lions Centre for Ophthalmic Studies (BPKLCOS). Materials and methods: Thirty-four VKC patients and thirty-four controls were included in this study. Tear samples were collected using micro- capillary glass tube method and tear IgE levels were measured using an enzyme – linked immunosorbent assay (ELISA). Results: There was high concentration of tear IgE level in VKC (95.09IU/ml) than in controls (1.63IU/ml) though the difference was not statistically significant (p=0.16). No statistically significant difference was observed in male and female gender within VKC group and when compared with control group (in male group, p=0.21 and in female group, p=0.26). There was no statistically significant difference observed in tear IgE level in different age groups within VKC group and when compared with control group (p=0.30). The result did not show any significant difference in tear IgE level with respect to the duration of the disease (p=0.23).There was no statistically significant difference in tear IgE level with different episodes of VKC (p=0.69). No statistically significant difference of IgE concentration in tear was seen among different types of VKC (p=0.53) and grades of tarsal and limbal papillae (p= 0.72). Conclusion: There was high concentration of tear IgE level observed in VKC. Key words: Vernal keratoconjunctivitis, Tearfilm, IgE level, Type I hypersensitivity reaction, Type IV hupersensitivity reaction. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/1238 | |
| dc.language.iso | en_US | |
| dc.publisher | Kathmandu University | |
| dc.title | Tearfilm immunoglobulin E (IgE) level in vernal keratoconjunctivitis by ELISA | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 108 | |
| oaire.citation.startPage | 104 | |
| relation.isJournalIssueOfPublication | 7ac6c163-bedc-4889-a694-6d22d79eb9bb | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 7ac6c163-bedc-4889-a694-6d22d79eb9bb | |
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