Publication: Study of clinical profile and antibiotic sensitivity pattern in culture positive typhoid fever cases
Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Objectives: The present study was designed to analyze the clinical profile and antibiotic sensitivity pattern in the
cases of culture positive typhoid fever.
Method: The study was conducted over a period of 1year. Total of 46 culture positive cases of Typhoid fever were
included in the study. The sensitivity pattern of isolates from blood culture was recorded. The modes of
presentation, clinical course, lab investigation reports were also recorded.
Results: Out of 46 cases, 33 (71.7%) were males and 13 (28.3%) were females. Average age of presentation was
26.17 years. Fever was present in all patients. Resistance of S .typhi to amoxycillin, chloramphenicol and co-
trimoxazole were significantly high. Ciprofloxacin showed resistance in 2 (4.3%) cases. Sensitivity to ceftriaxone
was 100% in our study.
Conclusion: Typhoid fever is one of the most common health problem in Nepal. Various drugs are being used in the
treatment of typhoid fever, in the mean time resistance to many of them are emerging. An appropriate antibiotic has
to be initiated only after culture sensitivity in typhoid fever.
Keywords: Typhoid fever, S. typhi, Sensitivity, Drug resistance