Publication: Propranolol is effective in decreasing stress response due to airway manipulation and CO2 pneumoperitoneum in patients undergoing laparoscopic cholecystectomy
Date
2005
Authors
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Journal ISSN
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Publisher
Kathmandu University
Abstract
Purpose: to study the effect of Propranolol on hemodynamic response due to airway manipulation and carbon
dioxide pneumoperitoneum on laparoscopic cholecystectomy cases. Methods: 63 patients undergoing laparoscopic
cholecystectomy under general anaesthesia were randomly divided into 3 groups; group 1 received 1.0 mg of
Propranolol, group 2 received 0.5 mg of Propranolol and group 3 received 1 ml saline 5 minutes before induction of
anaesthesia. Haemodynamic parameters were recorded for every 5 minutes from basal to 5 minutes after extubation
and analyzed. Results: Balanced anaesthesia used in our set up is effective in decreasing stress response due to
airway manipulation (laryngoscopy and endotracheal intubation) but not effective in that due to CO2
pneumoperitoneum. Propranolol 1 mg 5 minutes before anaesthesia is effective in decreasing stress response due to
airway manipulation and CO2 pneumoperitoneum in these groups of patients. Conclusion: Propranolol effectively
blunts the stress response due to CO2 pneumoperitoneum during laparoscopic cholecystectomy.
Key words: Propranolol, laparoscopy, stress response, CO2 pneumoperitoneum