Publication: Trend of bacteriological profile and antibiotics sensitivity pattern in neonates with late onset sepsis
| dc.contributor.author | Sah, Love Kumar | |
| dc.contributor.author | Pareek, Prince | |
| dc.contributor.author | Suryawanshi, Sonali | |
| dc.contributor.author | Banait, Nishant | |
| dc.contributor.author | Suryawanshi, Pradeep | |
| dc.date.accessioned | 2025-08-17T09:02:17Z | |
| dc.date.available | 2025-08-17T09:02:17Z | |
| dc.date.issued | 2025 | |
| dc.description | Department of Pediatrics, Madhesh Institute of Health Sciences, Janakpur, Nepal Consultant Neonatologist, Department of Pediatrics, ESIC Medical College, Faridabad, Haryana- 121001, India Assistant Professor, Department of Pharmacology, Bharati Vidyapeeth University Medical College, Pune-Satara Road, Pune, Maharashtra- 411043, India Assistant Professor, Department of Pediatrics, AIIMS, Nagpur, Maharashtra-441108, India Professor and Head, Department of Neonatology, Bharati Vidyapeeth University Medical College, Pune-Satara Road, Pune, Maharashtra- 411043, India | |
| dc.description.abstract | ABSTRACT: Background: Neonatal sepsis is a major cause of morbidity and mortality in low- and middle-income countries (LMICs). It is categorized as early onset sepsis (EOS, ≤72 hours) and late onset sepsis (LOS, >72 hours). The World Health Organization (WHO) has emphasized antibiotic stewardship. In LMICs, antibiograms are crucial where sepsis significantly contributes to neonatal deaths. Objective: To analyze trends in bacteriological profile and antibiotics sensitivity in neonates with Late Onset Sep- sis (LOS). Methods: This was a 10-year retrospective study of culture-proven LOS cases. Demographics, isolate types, and sensitivity patterns were recorded. Multidrug-resistant (MDR) gram-negative isolates were defined as resistance to ≥3 of 5 antibiotic classes: extended-spectrum cephalosporins, carbapenems, aminoglycosides, fluoroquinolones, and piperacillin-tazobactam. Results: Among 14,336 NICU admissions (2010–2019), 6092 (42.5%) were evaluated for sepsis, and 647 (10.6%) had culture-positive LOS. Gram-negative organisms comprised 488 (75.3%) isolates—Klebsiella (35.3%), E. coli (13.3%), and Acinetobacter (10.5%) were most common. Gram-positive isolates (24.7%) included S. aureus (9.4%), coagulase- negative staphylococci (10.5%), and Enterococcus (4.8%). High MDR rates were observed in Klebsiella (56.3%), E. coli (56.9%), and Acinetobacter (86.8%). Methicillin resistance was seen in 77.3% of S. aureus and 74.2% of Enterococcus. Conclusions: Alarming antimicrobial resistance in both gram-negative and gram-positive organisms calls for urgent at- tention. Antibiotic stewardship and regular antibiogram surveillance are essential to develop effective hospital policies. | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/1683 | |
| dc.language.iso | en_US | |
| dc.publisher | Madhesh Institute of Health Sciences (MIHS) | |
| dc.title | Trend of bacteriological profile and antibiotics sensitivity pattern in neonates with late onset sepsis | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 15 | |
| oaire.citation.startPage | 11 | |
| relation.isJournalIssueOfPublication | 6a3709b0-91e5-4b0f-8c02-92658e57e4dc | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 6a3709b0-91e5-4b0f-8c02-92658e57e4dc | |
| relation.isJournalOfPublication | d4600a08-1f72-4625-8a43-fa818d03ff5b |