Publication: Oral administration of intravenous solution of midazolam mixed in syrup of paracetamol is an effective way of premedicating children undergoing surgery under general anaesthesia
Date
2007
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
Abstract
Objective: The purpose of this study was to evaluate the efficacy of injection midazolam administered by oral route
mixed in paracetamol syrup as a premedication in children undergoing surgery.
Methods: 60 children undergoing elective hernia repair under general anaesthesia were randomized into two
groups: the study group (group A) was given oral midazolam 0.5mg/kg (mixed in paracetamol syrup) and the
control group (group B) was given just the paracetamol syrup before bringing them inside the operating theater.
They were evaluated for ease of separation from their parents, ease of i.v. cannulation and induction, and for
recovery time from anaesthesia.
Results: it was found that in group A-96.7% of children showed satisfactory parent child separation while in group
B- only 53.3% of children showed satisfactory separation (P < 0.05). Similarly in group A -73.3 % of children shad
satisfactory induction while in group B only 33.3% of children had satisfactory induction. The recovery time from
general anaesthesia did not differ in the two groups. No significant peri operative complications directly related to
oral midazolam was noted.
Conclusion: It was concluded that injection midazolam mixed in syrup paracetamol administered orally is a
convenient and efficient method of premedicating children undergoing general anaesthesia. Parent-child separation
and induction of anaesthesia was smooth and the recovery uneventful in children premedicated with oral midazolam.
Key words: Anxiety, midazolam, paracetamol, premedication, oral, parent-child separation, induction, recovery.
Description
S Shrestha
Lecturer Department of Anaesthesiology and IC, KMCTH
BR Shrestha
Assistant Professor Department of Anaesthesiology and IC, KMCTH