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Cerebral Hemodyanamics in Stable Preterm Infants Before and After Packed Cell Transfusion Authors

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creativeworkseries.issnISSN 1990-7974 eISSN 1990-7982
dc.contributor.authorChetan, Chinmay
dc.contributor.authorZaw, Nyein Nyein
dc.contributor.authorSuryawanshi, Pradeep
dc.contributor.authorBanait, Nishant
dc.contributor.authorPareek, Prince
dc.contributor.authorDeshpande, Sujata
dc.contributor.authorGupta, Bhvya
dc.contributor.authorGaregrat, Reema
dc.date.accessioned2025-11-26T09:18:23Z
dc.date.available2025-11-26T09:18:23Z
dc.date.issued2021
dc.descriptionChinmay Chetan Department of Neonatology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India and Department of Neonatology, Bharati Vidyapeeth Medical College Hospital and Research Centre, Pune (Maharashtra), India Nyein Nyein Zaw Department of Neonatology, Women and Children Hospital, Taunggyi, Myanmar Pradeep Suryawanshi 1- Department of Neonatology, Bharati Vidyapeeth Medical College Hospital & Research Centre, Pune (Maharashtra), India Nishant Banait Department of Neonatology, AIIMS, Nagpur, India Prince Pareek Department of Neonatology, Bharati Vidyapeeth Medical College Hospital and Research Centre, Pune (Maharashtra), India Sujata Deshpande Department of Neonatology, Bharati Vidyapeeth Medical College Hospital and Research Centre, Pune (Maharashtra), India Bhvya Gupta Sparsh superspeciality hospital, Ambala, India Reema Garegrat Department of Neonatology, Bharati Vidyapeeth Medical College Hospital and Research Centre, Pune (Maharashtra), India
dc.description.abstractAbstract: Introduction: In a year, around 3.5 million preterm deliveries occur in India alone. Some of these babies will require packed cell volume (PCV) transfusion. There is a paucity of robust data on effect of blood transfusions on the cerebral hemodynamic from India. This study was done to see the effect of PCV transfusion on blood flow velocities and resistive index (RI) of anterior cerebral artery (ACA) in stable preterm infants. Methods: A prospective observational study was conducted in a tertiary care hospital in Pune, India. All stable preterm infants (< 37 weeks) receiving PCV transfusion were enrolled. USG Doppler study of ACA was done before and after PCV transfusion. Peak systolic velocity (PSV), end-diastolic velocity (EDV) and RI were measured pre and post PCV transfusion. Results: Thirty infants were included in the study, with median gestation age of 28.8 {interquartile range (IQR), 27-30.55} weeks and median birth weight of 970 {interquartile range (IQR), 869.5 - 1190} grams. There was a significant decrease in PSV pre and post PCV transfusion - 58.46 (± 18.44) cm / sec and 46.34 (± 13.93) cm / sec respectively (p value < 0.001). Changes in RI and EDV were non-significant. Conclusions: PCV transfusion significantly decreased PSV, reflecting improved cerebral oxygenation, and decreased cardiac output after correction of anaemia. Laboratory threshold for PCV transfusion in stable preterm infants are not known. USG Doppler study has the potential to provide one of the objective criteria for PCV transfusion in these infants though large scale randomized controlled trials are needed to prove its efficacy.
dc.identifierhttps://doi.org/10.3126/jnps.v41i3.36444
dc.identifier.urihttps://hdl.handle.net/20.500.14572/3276
dc.language.isoen_US
dc.publisherNepal Paediatric Society (JNPS)
dc.subjectEnd diastolic velocity
dc.subjectPacked cell volume transfusion
dc.subjectPeak systolic velocity
dc.subjectResistive index
dc.subjectStable preterm infants
dc.subjectUSG Doppler study
dc.titleCerebral Hemodyanamics in Stable Preterm Infants Before and After Packed Cell Transfusion Authors
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage357
oaire.citation.startPage353
relation.isJournalIssueOfPublication0b99c152-1968-4a9d-81aa-91bd247df181
relation.isJournalIssueOfPublication.latestForDiscovery0b99c152-1968-4a9d-81aa-91bd247df181
relation.isJournalOfPublication6f9be05c-05a9-4a3e-a5b5-a19a15ab042c

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