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Pure Autonomic Failure: A Case Report of Recurrent Orthostatic Hypotension

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creativeworkseries.issnJNMA Print ISSN: 0028-2715; Online ISSN: 1815-672X
dc.contributor.authorKhatri, Prabin
dc.contributor.authorPanth, Himal
dc.contributor.authorKhadka, Sabina
dc.contributor.authorThapa, Pramila
dc.contributor.authorRegmi, Rajshree
dc.contributor.authorShah, Sunil
dc.contributor.authorGami, Sumit
dc.contributor.authorUpadhyaya, Ashutosh
dc.contributor.authorAlam, Mohammad Rizwan
dc.contributor.authorSharma, Srijana
dc.date.accessioned2026-02-26T07:03:00Z
dc.date.available2026-02-26T07:03:00Z
dc.date.issued2021
dc.descriptionPrabin Khatri Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Nepal Himal Panth Universal College of Medical Sciences, Bhairahawa, Nepal Sabina Khadka Nepalese Army Institute of Health Sciences, Sanobharyang, Kathmandu, Nepal Pramila Thapa Lumbini Medical College, Palpa, Nepal Rajshree Regmi Lumbini Medical College, Palpa, Nepal Sunil Shah Universal College of Medical Sciences, Bhairahawa, Nepal Sumit Gami Universal College of Medical Sciences, Bhairahawa, Nepal Ashutosh Upadhyaya Universal College of Medical Sciences, Bhairahawa, Nepal Mohammad Rizwan Alam Universal College of Medical Sciences, Bhairahawa, Nepal Srijana Sharma Universal College of Medical Sciences, Bhairahawa, Nepal
dc.description.abstractAbstract: Pure autonomic failure is a neurodegenerative disorder affecting the autonomic nervous system which clinically presents with orthostatic hypotension. It is a diagnosis of exclusion after detailed clinical examinations and relevant investigations. Here, we discuss a case of 68 years old male who had complaints of multiple episodes of loss of consciousness on standing from a sitting position for the last 3 years. The diagnosis was considered by clinical examinations revealing autonomic dysfunctions with normal appropriate investigations. The patient was treated successfully with midodrine, fludrocortisone, and other non-pharmacological interventions. We focused on doing various autonomic dysfunction tests in the evaluation of a patient with recurrent orthostatic hypotension. We suspect that pure autonomic failure might not have been considered in the differential diagnosis of recurrent orthostatic hypotension and suggest that it is to be kept as a differential in such a scenario. Midodrine has an effective role in syncope due to sympathetic vasoconstrictor failure.
dc.identifierhttps://doi.org/10.31729/jnma.6480
dc.identifier.urihttps://hdl.handle.net/20.500.14572/4951
dc.language.isoen_US
dc.publisherNepal Medical Association
dc.subjectmidodrine
dc.subjectorthostatic hypotension
dc.subjectpure autonomic failure
dc.titlePure Autonomic Failure: A Case Report of Recurrent Orthostatic Hypotension
dc.typeArticle
dspace.entity.typePublication
local.article.typeCase Report
oaire.citation.endPage592
oaire.citation.startPage589
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relation.isJournalIssueOfPublication.latestForDiscovery6b98c94f-5683-4340-88a0-99371bdd96de
relation.isJournalOfPublicatione6e146a0-0ece-4aba-aa0a-6ccfbd10a12a

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