Article: Study on blakpc gene among klebsiella pneumoniae from the clinical specimens in a tertiary care hospital, Kathmandu, Nepal
| creativeworkseries.issn | Online ISSN: 2676-1424; Print ISSN: 2676-1319 | |
| dc.contributor.author | Khadka, Shusila | |
| dc.contributor.author | Adhikari, Ram Prasad | |
| dc.contributor.author | Khanal, Laxmi Kant | |
| dc.contributor.author | Pandey, Ritu | |
| dc.contributor.author | Sah, Anil Kumar | |
| dc.contributor.author | Sapkota, Jyotshna | |
| dc.creator.affiliation | Department of Microbiology, Nepal Medical College Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu | |
| dc.creator.affiliation | Department of Microbiology, Nepal Medical College Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu | |
| dc.creator.affiliation | Department of Microbiology, Nepal Medical College Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu | |
| dc.creator.affiliation | Department of Microbiology, Nepal Medical College Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu | |
| dc.creator.affiliation | Department of Research, Annapurna Neuro Hospital, Maitighar, Kathmandu | |
| dc.creator.affiliation | Department of Microbiology, Nepal Medical College Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu | |
| dc.date.accessioned | 2026-10-08T08:11:35Z | |
| dc.date.available | 2026-10-08T08:11:35Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Abstract: Multidrug resistance (MDR) among Klebsiella pneumoniae: a common nosocomial pathogen, has been a great concern for managing its infections effectively worldwide. Production of KPCs (Klebsiella pneumoniae carbapenemases) is one of the most important mechanisms in this bacterium, making it resistant to carbapenems: the most commonly used antibiotics for treating MDR organisms. This study was done to detect KPC genotypes (blaKPC-1, blaKPC-2, blaKPC-3) among K. pneumoniae isolates and to determine their antimicrobial susceptibility patterns.A descriptive cross-sectional study was conducted from September 2023 to February 2024 in a total of 82 non-repetitive clinical isolates of K. pneumoniae at Clinical Microbiology Laboratory of Nepal Medical College Teaching Hospital (NMCTH), Nepal. More than one-third (30/82; 36.58%) of the isolates were MDR. Out of the total isolates, 18 (21.95%) were resistant to carbapenems. Of these, 14 (77.77%) isolates possessed blaKPC-2 gene. All isolates were susceptible to Polymyxin and Colistin sulphate. Almost half of the isolates were resistant to Cephalophorins (Cefixime- 43.90%, Ceftriaxone-41.0% and Ceftazidime-43.9%). Presence of KPC producing K. pneumoniae isolates in our set-up, with higher level of resistance to multiple antibiotics highlights the need for continuous monitoring and endorsement of control strategies to tackle the challenges created by this bacterial pathogen. | |
| dc.identifier.doi | https://doi.org/10.3126/nmcj.v27i2.80544 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/8058 | |
| dc.language.iso | en_US | |
| dc.publisher | Nepal Medical College Pvt. Ltd. | |
| dc.subject | Klebsiella pneumoniae | |
| dc.subject | KPC | |
| dc.subject | BlaKPC | |
| dc.title | Study on blakpc gene among klebsiella pneumoniae from the clinical specimens in a tertiary care hospital, Kathmandu, Nepal | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 154 | |
| oaire.citation.startPage | 149 | |
| relation.isJournalIssueOfPublication | d6f8668b-63e4-40af-9dee-3e2b689fa22a | |
| relation.isJournalIssueOfPublication.latestForDiscovery | d6f8668b-63e4-40af-9dee-3e2b689fa22a | |
| relation.isJournalOfPublication | 865934c8-5e95-468c-8ca6-7bb2529e4064 |