Publication: Evaluation of endometrial changes and p53 expression in tamoxifen treated women: Comparison of various methods
| creativeworkseries.issn | 1812-2027 | |
| dc.contributor.author | HP, Pokharel | |
| dc.contributor.author | N, Bhatla | |
| dc.contributor.author | A, Kriplani | |
| dc.contributor.author | A, Mukhopadhyay | |
| dc.contributor.author | A, Srivastava | |
| dc.contributor.author | R, Ralhan | |
| dc.date.accessioned | 2025-07-22T05:39:11Z | |
| dc.date.available | 2025-07-22T05:39:11Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Objective: To compare transvaginal sonography (TVS), sonohysterography (SHG), hysteroscopy and endometrial aspiration (EA) and p53 expression in assessing endometrial abnormalities in women on tamoxifen. Methods: In a cross sectional study of 50 pre- and post-menopausal women receiving tamoxifen for > 2 years, all participants underwent TVS and EA. Those with endometrial thickness > 4 mm on TVS underwent hysteroscopy and SHG. Serum p53 antibody and p53 immunohistochemistry were tested in all women. Results: The sensitivity and specificity when compared with histopathology as the reference standard were as follows: TVS 100% and 33.3%, SHG 85.7% and 50%, hysteroscopy 92.8% and 80.8%, serum p53 50% and 83.3%, and p53 immunohistochemistry 57.1% and 61.1%. Prevalence of endometrial abnormalities was not significantly different in asymptomatic and symptomatic women. Conclusion: Tamoxifen-users require routine testing for endometrial evaluation. TVS followed by hysteroscopy and biopsy is an effective option. p53 expression correlates with histological abnormalities. Key words: Tamoxifen, Sonography, Sonohysterography, Hysteroscopy, Endometrium, p53 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14572/502 | |
| dc.language.iso | en_US | |
| dc.publisher | Kathmandu University | |
| dc.title | Evaluation of endometrial changes and p53 expression in tamoxifen treated women: Comparison of various methods | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| local.article.type | Original Article | |
| oaire.citation.endPage | 151 | |
| oaire.citation.startPage | 145 | |
| relation.isJournalIssueOfPublication | 2571981e-5785-4142-970b-863aa4219be4 | |
| relation.isJournalIssueOfPublication.latestForDiscovery | 2571981e-5785-4142-970b-863aa4219be4 | |
| relation.isJournalOfPublication | a782b7ff-cf89-4178-ad1c-11ed89cfe1bd |