Publication: Neonatal Purpura Fulminans Authors
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Neonatal purpura fulminans is a rare, life-threatening condition of dermal microvascular thrombosis associated with DIC and perivascular hemorrhage in the newborn period associated with high morbidity and mortality [1]. Gram negative organisms and Staphylococcus species are the most common causes of the acute infectious type [2]. It may be congenital, as a result of protein C and S deficiency, or acquired due to severe infection. It is characterized by the rapid spread of symmetrical, bluish-black hemorrhages into the skin, affecting mainly the extensor surfaces of the extremities and showing a tendency to deep necrosis and the formation of sero-sanguineous bullae. The haemorrhagic areas are well defined and are surrounded by oedema. These lesions are accompanied by a high fever and intense systemic symptoms.
Description
D Sharma
Department of Paediatrics, Pt.B.D.S PGIMS Rohtak, Haryana
J Yadav
Department of Paediatrics, Pt.B.D.S PGIMS Rohtak, Haryana
Keywords
Neonatal purpura fulminans, skin necrosis, disseminated intravascular coagulation