Publication: Assessment of Prescribing Pattern and Safety Profile of Drugs Used in Intranasal Route in Paediatric Age Group of Patients in a Tertiary Care Hospital
Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Recently there has been an increased preference for intranasal delivery of drugs
due to highly vascular nasal mucosa, bypassing first pass metabolism and the blood
brain barrier (BBB) lead in quick drug absorption to the systemic circulation and
direct access to brain from olfactory region. For pediatric patients this route offers
significant benefits over injections or oral routes, like increased compliance, easy
administration, and minimal side effects.
Objective
Assessment of prescription pattern of drugs and safety profile of drugs used by
intranasal route in paediatric age group.
Method
Our study was a prospective observational study paediatric age group of patients
conducted in the departments of Pharmacology, Paediatrics and Otorhinolaryngology
of Burdwan Medical College and Hospital, Burdwan. Data were collected in CRF and
frequency distribution of collected data done. Microsoft Excel 2010 was used for
analysis.
Result
Common age group was infants. Males were more in number. Most common
indication was epistaxis. Intranasal drugs per prescription were 1.05. Most
commonly prescribed intranasal drug was nasal saline. Nasal decongestant was the
most common prescribed medication. Nasal drops were the most common dose
formulation.
Conclusion
Intranasal drug prescribing in our study was mainly aimed for treating local problems,
very few being for systemic action. Some prescribing indicators like prescribing by
generic name and prescribing from national essential drug lists were acceptable with
scope for improvement. Average number of drugs per prescription and antibiotic
use was high. Adverse events after intranasal drug use were primarily local and nose
related.
KEY WORDS
Drug delivery, Intranasal, Paediatric, Prescription, Safety
Description
Bhadury A,1 Roy UK,2 Ghosh T,3 Barman D,4 Mandal P5
1Department of Pharmacology
Burdwan Medical College and Hospital
Burdwan, India
2Department of Pharmacology
Raiganj Govt. Medical College and Hospital,
West Bengal, India
3Department of Paediatrics
4Department of Otorhinolaryngology
Burdwan Medical College and Hospital
Burdwan, India
5Department of Pharmacology
Raiganj Govt. Medical College and Hospital,
West Bengal, India
Keywords
Drug delivery, Intranasal, Paediatric, Prescription, Safety