Publication: Risk factors of Multidrug Resistant Tuberculosis in central Nepal: A pilot study
Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Introduction
Tuberculosis is the most widespread infectious disease in Nepal and poses a serious
threat to the health and development of the country. Incidences of drug resistant
tuberculosis in Nepal are increasing and this tuberculosisis a major threat to
successfully controlling tuberculosis .
Objective
The general objective of the study was to assess the risk factors of multi-drug resistant
tuberculosis among the patients attending the National Tuberculosis Centre, Bhaktpur
Nepal.
Methods
An observational study/ case-control study with a Atotal number of 55 multi-drug
resistant tuberculosis cases and 55 controls. The study was conducted among the
patient attending in the National Tuberculosis Centre , Bhaktpur Nepal for six months,
between May–October 2010. sImulti-drug resistant tuberculosis wasThe collected
data was analysed in SPSS 11.5 version. The association between categorical variables
were analysed by chi-square tests, OR and their 95% CI were measured.
Results
The total number of patients used for the study was 110, of which among them 55
were cases and 55 were controls . Our study revealed that there were significant
associations between history of prior TB MDR-TB OR =2.799 (95 % CI 1.159 to 6.667)
(p=0.020); smoking habit OR =2.350 and (95%CI 1.071 to 5.159) (p=0.032); social stigma
social stigma OR 2.655 (95%CI r 1.071 to 5.159) (p=0.013); knowledge on MDR-TB OR
=9.643 (95% CI 3.339 to 27.846) (p < 0.001)and knowledge on DOTS Plus OR=16.714
(95% CI is ranging from 4.656 to 60.008) (p< 0.001). However, there was no association
found between alcohol drinking habits and ventilation in the room.
Conclusion
Our study revealed that there were significant associations between history of
prior tuberculosis, smoking habit social stigma social stigma, knowledge on multi-
drug resistant tuberculosis and knowledge on DOTS Plus with multi-drug resistant
tuberculosis However there was no association between alcohol drinking habit and
ventilation in room with multi-drug resistant tuberculosis.
Key Words
directly observed treatment short course-plus, multidrug-resistant tuberculosis, risk
factors
Description
Marahatta SB1, Kaewkungwal J2, Ramasoota P3, Singhasivanon P4
1 Ph.D Student, Department of Tropical Hygiene, 2,4Department of Tropical Hygiene, 3Department of Social and Environmental Medicine, Faculty of Tropical Medicine Mahidol University, Thailand