Publication: Intravenous Immunoglobulin in Neonatal Sepsis
Date
2013
Authors
Li, Jiang
Gautam, Mahesh Kumar
Article Type
Review Article
Journal Title
Journal ISSN
ISSN 1990-7974 eISSN 1990-7982
Volume Title
Pages
Pages: 125 - 128
Publisher
Nepal Paediatric Society (JNPS)
Abstract
Abstract:
Neonatal sepsis remains the major cause of mortality and morbidity including neurodevelopmental impairment and prolonged hospital stay in newborn infants. Despite of advances in technology and optimal antibiotic treatment, incidence of neonatal sepsis and its complications remains unacceptably high especially in developing countries. Premature neonates in particular are at higher risk due to developmentally immature host defense mechanisms. Though not approved by Food and Drug Administration (FDA) U.S.A, off label use of intravenous immunoglobulin continues in many countries. Recent evidences showed no significant decrease in the mortality rate or other outcomes when intravenous immunoglobulin is administered in addition to standard therapies. Hence, use of intravenous immunoglobulin in suspected or proven neonatal sepsis is not recommended. The expense of prophylactic use of intravenous immunoglobulin administration for both term and preterm newborn population, given the minimal benefit is not justified. Future studies are required which should focus on other prophylactic or adjuvant treatment modalities in addition to the standard therapy in neonatal sepsis.
Description
Jiang Li
School of Medicine, ZhongDa Hospital, Southeast University
Mahesh Kumar Gautam
School of Medicine, ZhongDa Hospital, Southeast University
Keywords
Neonatal sepsis, Intravenous immunoglobulin
Identifier
https://doi.org/10.3126/jnps.v33i2.7400