Publication: Evaluation of Lipid Peroxidation and Antioxidants’ Status in Metabolic Syndrome
Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Metabolic syndrome is a constellation of physical conditions and metabolic
abnormalities, commonly occurring together, that increases an individual’s risk for
development of type 2 diabetes mellitus and cardiovascular diseases. Oxidative stress
is associated with diabetes, hypertension and other cardiovascular diseases while the
role of oxidative stress in pathogenesis of MS is not clearly defined.
Objectives
The study aims to find out the prevalence of metabolic syndrome in faculty and staff
members at BP Koirala Institute of Health Sciences, Dharan, Nepal and to evaluate
oxidative stress levels in subjects with metabolic syndrome.
Methods
118 healthy participants working at B. P. Koirala Institute of Health Sciences, Dharan,
Nepal were selected at random for this cross-sectional study and blood samples were
collected for the estimation of the following biochemical analytes; fasting glucose;
triglycerides; total cholesterol; high density lipoprotein cholesterol; Albumin; uric acid;
Bilirubin; Malondialdehyde; Catalase; Glutathione peroxidase; Superoxide Dismutase;
Glutathione; vitamin C; and lastly vitamin E.
Results
In this cross-sectional study, 39% subjects were diagnosed with metabolic syndrome
, particularly in sedentary subjects. There was no difference in oxidative stress except
significant rises in serum uric acid levels and catalase activity in subjects diagnosed with
metabolic syndrome .
Conclusion
The prevalence of metabolic syndrome is higher without oxidative stress in this study,
which suggests that oxidative stress does not contribute to the pathogenesis of MS in
otherwise healthy subjects.
Key Words
antioxidants, lipid peroxidation, metabolic syndrome, oxidative stress
Description
Shrestha S1, Chandra L2, Aryal M3, Das BKL4, Pandey S5 , Baral N6
1,4-6Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan, Nepal 2Department of Biochemistry, Maulana Azad Medical College, New Delhi,
India 3Department of Biochemistry, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal