Publication:
Evaluation of Quality Parameters of Light Sensitive Drugs Marketed in Nepal

creativeworkseries.issn1999-6217
dc.contributor.authorMaharjan, Sajan
dc.contributor.authorDhungel, Subhash Kumar
dc.date.accessioned2025-07-27T06:56:33Z
dc.date.available2025-07-27T06:56:33Z
dc.date.issued2023
dc.descriptionSajan Maharjan CiST College, Sangam Chowk, New Baneshwor, Kathmandu, Nepal Subhash Kumar Dhungel CiST College, Sangam Chowk, New Baneshwor, Kathmandu, Nepal
dc.description.abstractAbstract Background: Photosensitivity is the response of drug or drug product to the exposure of solar, UV and visible light in the solid, semisolid, or liquid state that leads to a physical or chemical change. Exposure to light is a concern with numerous medications due to the potential for photo degradation or other chemical reactions that affect drug stability. Methods: Out of all the registered brands in Department of Drug Administration, 9 brands of Rabeprazole tablets, 5 brands of Promethazine tablets and 5 brands of methylcobalamin tablets were selected and were subjected for testing and analysis for various quality parameters as per pharmacopoeia. The labels of the collected medicine were analyzed. The obtained data were entered and analyzed in Microsoft office excel 2019. Results: Eleven products did not comply with the existing regulatory requirement on labeling system of medicine as per Regulation of Standard of drugs. There was no uniformity in mentioning the self-life. Similarly, large variation was seen on price of same generic drugs. Information regarding storage conditions, direction for use and category of the drug were lacking in the label of some brands of medicines.Upon Laboratory analysis, two brands of promethazine tablets and three brands of Rabeprazole tablets were found substandard. Drug content of all the brands of Methylcobalamin was found to contain overage. Conclusions: The result of this study indicates that substandard medicines are abundant in Nepalese market. There is weak regulation monitoring which have resulted in no uniformity in similar pharmaceutical products too. Hence, stringent regulatory monitoring is required to assessthe quality of pharmaceutical products in the Nepalese market. Keywords: Light sensitive drugs; substandard drugs; quality of drugs
dc.identifierhttps://doi.org/10.33314/jnhrc.v21i1.4131
dc.identifier.urihttps://hdl.handle.net/20.500.14572/733
dc.language.isoen_US
dc.publisherNepal Health Research Council
dc.titleEvaluation of Quality Parameters of Light Sensitive Drugs Marketed in Nepal
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage22
oaire.citation.startPage19
relation.isJournalIssueOfPublication0b756562-9f28-45a1-a148-be81ddb98bf5
relation.isJournalIssueOfPublication.latestForDiscovery0b756562-9f28-45a1-a148-be81ddb98bf5
relation.isJournalOfPublication40bd2739-8b19-447c-be60-723a1bdd1dcd

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