Publication: Hereditary Vitamin-D Dependent Rickets Type II: A Case Report
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Nepal Medical Association
Abstract
Abstract:
Hereditary vitamin D dependent rickets type II is a rare genetic disorder in children characterized by early onset of rickets and deranged biochemical parameters. Low serum calcium level, high alkaline phosphatase, high parathyroid hormone, and high values of 1,25-dihydroxy vitamin D are characteristic biochemical findings. We are reporting a rare case of Vitamin D Dependent Rickets and subsequent improvement after addition of cinacalcet. This is a case report of a 2.5-year-child with Hereditary Vitamin D Dependent Rickets type II receiving cinacalcet as adjunct to oral calcium and calcitriol. Oral cinacalcet (0.25mg/kg/day) was added to the regimen as an adjunct after treatment failure with high dose of oral calcium and calcitriol. A significant improvement in radiological findings and normal homeostasis of calcium, phosphate and parathyroid hormone was achieved after initiation of cinacalcet.
Description
Neela Sunuwar
B. P. Koirala Institute of Health Sciences, Dharan, Nepal
https://orcid.org/0000-0002-7377-8062
Swotantra Gautam
Kathmandu University School of Medical Sciences, Dhulikhel, Nepal
Anuradha Twayana
Kathmandu University School of Medical Sciences, Dhulikhel, Nepal
Saroj Adhikari Yadav
Department of Paediatrics, Patan Academy of Health Sciences, Lalitpur, Nepal.
Firoz Anjum
Department of Paediatrics, Patan Academy of Health Sciences, Lalitpur, Nepal
Kriti Kandel
Department of Paediatrics, Patan Academy of Health Sciences, Lalitpur, Nepal
Keywords
cinacalcet, rickets, vitamin D