Publication: Association of Different Biochemical and Hemodynamic Characteristic with Type 2 Diabetes Mellitus and Hypertension in Nephrolithiasis Patients
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Date
2023
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Although Nephrolithiasis is a common condition caused by a wide variety of
metabolic or environmental disturbances, its being one of the major factor of
morbidity. Incidence of kidney stone disease (KSD) is highly affected by metabolic
disorders and change in blood pressure and glucose.
Objective
To find out association of different biochemical and hemodynamic parameters with
various glycemic status and hypertension in kidney stone disease.
Method
A cross sectional study was conducted in patients diagnosed as nephrolithiasis by
using re¬nal ultrasonography and underwent nephrectomy between January 2019
to January 2021 in Shahid Dharmabhakta National Transplant Centre (SDNTC). A
total of 100 subjects with 60 male and 40 females were enrolled. Glycemic status
was categorized based on criteria of American Diabetes Association (ADA) and
hypertension was defined as BP ≥ 140/90 mm Hg in right arm supine position. All
biochemical and hemodynamic profile was carried out following standard protocol.
Result
Out of 100 patients enrolled, pre-diabetes accounted for 31% followed by diabetes
(4%). However, hypertension comprised of 66% in total subjects. Serum urea,
cholesterol and triglyceride level were found to be increased by 84.6%, 67.7%
and 64.7% respectively in diabetes followed by increase of 3.9%, 19.5% and 3.1%
respectively in prediabetes when compared to normal glycemic condition in
nephrolithiasis subjects. Serum fasting blood glucose, creatinine and uric acid level
was observed significantly higher (p=0.003, p=0.004, p < 0.001 respectively) in
hypertensive patients. Duration of hospital stay was also seen positively correlated
with hypertension.
Conclusion
Not only diabetes, prediabetes also manifests the increased risk of kidney stone
disease along with hypertension. There is significant impairment in renal function
and lipid profile based on diabetes mellitus and hypertension. Early identifying these
systemic diseases, different biochemical and hemodynamic parameters and proper
treatment accordingly may minimize risk and prevent serious complication in these
patients.
KEY WORDS
Diabetes mellitus, Hypertension, Nephrolithiasis
Description
Katwal BM,1 Gautam N,2 Shrestha S,3 Adhikari R,1 Baral H,1 Jha SK,4 Jha G5
1Department of Urology and Kidney Transplantation
Shahid Dharma National Transplant Center (SDNTC), Bhaktapur
2Department of Biochemistry
Universal College of Medical Sciences (UCMS), Bhairahawa
3Central Jail Hospital-Laboratory
Tripureshwor, Kathmandu
4Department of Radiology
Kanti Children’s Hospital,Maharajgunj, Kathmandu
5Department of Obsterics and Gynaecology
Patan Academy of Health Sciences, Patan, Lalitpur.
Keywords
Diabetes mellitus, Hypertension, Nephrolithiasis