Publication:
Sinonasal Mucormycosis Amidst the Second Wave of COVID-19 Pandemic; Clinical Spectrum and Outcome in a Tertiary Care Center in Nepal

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creativeworkseries.issn1812-2027
dc.contributor.authorGurung U
dc.contributor.authorDongol K
dc.contributor.authorPaudel S
dc.contributor.authorThapa, NM
dc.contributor.authorPradhananga, RB
dc.contributor.authorGyawali, BR
dc.contributor.authorShrestha GS
dc.date.accessioned2026-01-14T06:51:47Z
dc.date.available2026-01-14T06:51:47Z
dc.date.issued2024
dc.descriptionGurung U,1 Dongol K,1 Paudel S,2 Thapa NM,1 Pradhananga RB,1 Gyawali BR,1 Shrestha GS3 1Department of ENT-HNS 2Department of Radiology and Imaging 3Department of Critical Care Medicine Tribhuvan University Teaching Hospital Maharajgunj, Kathmandu, Nepal
dc.description.abstractABSTRACT Background Mucormycosis is an angioinvasive opportunistic fungal infection which surged during the second wave of COVID-19 pandemic. Objective This study assessed patient demographics, risk factors, clinical characteristics, and outcomes of sinonasal mucormycosis during the second wave of COVID-19 pandemic. Method The clinical records of patients with histologically proven sinonasal mucormycosis, admitted between May 2021 to October 2021, in a tertiary center were reviewed. Result There were 25 patients (18 males, 7 females). The age ranged from 16 to 70 years (mean 51 ± 9.5 years). Uncontrolled diabetes mellitus detected in 23 patients was the most common co-morbidity. COVID-19 infection was documented in 20 patients. The mean time of diagnosis was 12 days after the onset of COVID-19 infection. Based on the disease extent, six patients had sino-nasal, seven had rhino-orbital, and 12 had rhino-orbital-cerebral involvement. The most common first presenting symptom was orbital (17/25) followed by facial (5/25) and orodental (3/25). All patients received intravenous amphotericin B for 2 to 8 weeks. Maintenance with posaconazole ranged from 3 to 9 months. Sixteen patients underwent surgical debridement. Out of the 25 patients, 14 (56%) had good recovery. Poor outcome was observed mostly with intracranial involvement. Conclusion Uncontrolled diabetes mellitus was a common risk factor. Advanced disease at presentation was frequently encountered due to rapid extrasinus spread. Nearly 50% of patients had good recovery whilst poor outcome was observed, mostly with intracranial involvement. Adequate blood sugar control, early administration of antifungals, and aggressive surgical debridement are the mainstay of treatment. KEY WORDS COVID-19, Hyperglycemia, Mucor, Mucormycosis, Pandemic
dc.identifier.urihttps://hdl.handle.net/20.500.14572/4251
dc.language.isoen_US
dc.publisherKathmandu University
dc.subjectCOVID-19
dc.subjectHyperglycemia
dc.subjectMucor
dc.subjectMucormycosis
dc.subjectPandemic
dc.titleSinonasal Mucormycosis Amidst the Second Wave of COVID-19 Pandemic; Clinical Spectrum and Outcome in a Tertiary Care Center in Nepal
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage425
oaire.citation.startPage419
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relation.isJournalIssueOfPublication.latestForDiscoverye11bafba-6525-4c58-88d9-4eff4919cf29
relation.isJournalOfPublicationa782b7ff-cf89-4178-ad1c-11ed89cfe1bd

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