Publication: ORAL SUBMUCOUS FIBROSIS: A REVIEW ARTICLE ON ETIOPATHOGENESIS
Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Areca quid chewing related oral mucosal lesions are potential hazard to a large
population worldwide. Commercially freeze dried products such as pan masala,
guthka and mawa have high concentration of areca nut per chew and appear
to cause OSMF more rapidly than by self prepared conventional betel quid that
contain smaller amounts of areca nut. The basic constituent of areca nut is either
raw or dried or boiled or baked. Diverse agents including lime, tobacco, catechu,
cloves, saffron and leaf of piper betel leaves may form a part of formulation.
Many of the undesirable aspects of areca nut have been attributed to arecoline.
These chemical appear to interfere with the molecular processes of deposition
and or degradation of extracellular matrix molecules such as collagen, causing
imbalance in the normal process. The most likely events that take place with
regards to the above imbalance may be reduced phagocytosis of collagen by
fibroblasts, up or down regulation of copper dependent enzyme lysyl oxidase,
matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases .
It has been postulated that areca nut may also induce the development of the
disease by increased levels of cytokines in the lamina propria. Current evidence
implicates collagen related genes in susceptibility and pathogenesis of OSMF.
The individual mechanisms operating at various stages of the disease- initial,
intermediate and advanced–need further study in order to propose appropriate
therapeutic interventions.
KEYWORDS
Areca-nut, matrix metalloproteinases, oral sub mucous fibrosis.
Description
Tak J,1 Gupta N,2 Bali R1
1Department of Oral Pathology
2Department of Periodontics
Shree Bankey Bihari Dental College & Research Centre
National Highway-24, Masuri Canal
GHAZIABAD -201302
Uttar-Pradesh, INDIA