Publication: Tissue Polypeptide Specific Antigen as a Marker used to Determine the Liver Diseases
Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Kathmandu University
Abstract
ABSTRACT
Background
Tissue polypeptide specific antigen and its specific M3 epitope are increased
in malignant as well as in some benign diseases. The level of tissue polypeptide
specific antigen in serum is related mostly to proliferation capacity rather than
tumor mass and cell necrosis.
Objective
The aim of this study was to evaluate the levels of tissue polypeptide specific antigen
and other tumor markers in patients with liver cirrhosis, chronic active hepatitis
and hepatoma to determine if tissue polypeptide specific antigen is important to
other tumor markers in hepatoma patients.
Methods
Ninty-seven patients and 30 controls were included in the study. The patients were
divided into three subgroups as cirrhosis, hepatoma and chronic active hepatitis.
The levels of tissue polypeptide specific antigen, carcinoembryonic antigen, CA19.9,
alpha-fetoprotein and transaminases were determined in all patients.
Results
Tissue polypeptide specific antigen levels were significantly higher in all patients
than in the control group (p<0.005) According to Kruskal-Wallis test with regard to
subgroups, the differences in mean values of tissue polypeptide specific antigen and
alpha-fetoprotein were significant (p<0.0001 for both). There was a low correlation
between tissue polypeptide specific antigen and alpha-fetoprotein in the cirrhotic
and hepatoma groups, but these were significantly correlated in the chronic active
hepatitis group. The correlation coefficient between tissue polypeptide specific
antigen and transaminases in all patients was low.
Conclusions
Tissue polypeptide specific antigen is efficient for determining primary hepatoma
patients and also that this marker is specific for proliferation of cells.
KEY WORDS
liver diseases, marker, tissue polypeptide specific antigen
Description
Paul D,1 Biswas R2, Habib SH3
1Biomedical Research Group (BMRG), BIRDEM, Dhaka-1000, Bangladesh;
2North South University, Dhaka, Bangladesh;
3Bangladesh Diabetic Association, Dhaka, Bangladesh