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Clinicopathological Outcome of Early and Late Onset Renal Cell Carcinoma: An Observational Study

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creativeworkseries.issnISSN (Print) : 1993-2979 | ISSN (Online) : 1993-2987
dc.contributor.authorPandit, Durga
dc.contributor.authorPhuyal, Anjit
dc.contributor.authorGyawali, Milan
dc.contributor.authorGuragain, Bipin
dc.contributor.authorParajuli, Purushottam
dc.contributor.authorPradhan, Manish Man
dc.contributor.authorPoudyal, Sujeet
dc.contributor.authorChapagain, Suman
dc.contributor.authorLuitel, Bhojraj
dc.contributor.authorChalise, Pawan Raj
dc.contributor.authorSharma, Uttam Kumar
dc.contributor.authorGyawali, Prem
dc.date.accessioned2025-11-14T08:06:32Z
dc.date.available2025-11-14T08:06:32Z
dc.date.issued2024
dc.descriptionDurga Pandit Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Anjit Phuyal Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Milan Gyawali Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Bipin Guragain Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Purushottam Parajuli Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Manish Man Pradhan Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Sujeet Poudyal Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Suman Chapagain Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Bhojraj Luitel Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Pawan Raj Chalise Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Uttam Kumar Sharma Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author Prem Gyawali Department of Urology and Kidney Transplant Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Author
dc.description.abstractAbstract: Introduction Renal cell carcinoma (RCC) is considered a disease of old age and is typically found in the 6th-8th decade of life. The diagnosis of RCC is increasing more rapidly in younger age patients. This study was conducted to evaluate the clinicopathological pattern and outcome of early onset RCC and compare them with the older age group patients. Methods This was a single center observational study. All the patients undergoing radical or partial nephrectomy during the period of November 2019 to October 2022 for renal masses and whose final histopathology report showed RCC were included in the study. Clinicopathological patterns and outcome were compared between the two age groups. Results Among 47 patients, 17 (36.2%) patients were at or below the age of ≤46 years and 30 (63.8%) patients in older age group. There was significant difference in male (29): female (18) ratio between the two age groups (p < 0.005). Younger age patients (≤46 yrs) had higher stage of disease at presentation compared with the older age (>46 yrs) patients [tumor extension into major veins and perinephric tissue (T3) and above 26 vs 21] and they had significantly higher mortality rate (29.4% vs 3.3%, p =0.01). Conclusion Patients aged ≤46 years of age were more frequently affected by RCC with female predominance. Younger age group had higher stage of disease at presentation with higher mortality in comparison to older age group.
dc.identifierhttps://doi.org/10.59779/jiomnepal.1316
dc.identifier.urihttps://hdl.handle.net/20.500.14572/3172
dc.language.isoen_US
dc.publisherInstitute of Medicine, Tribhuvan University
dc.subjectClinicopathological
dc.subjectearly onset
dc.subjectlate onset
dc.subjectoutcome
dc.subjectrenal cell carcinoma
dc.titleClinicopathological Outcome of Early and Late Onset Renal Cell Carcinoma: An Observational Study
dc.typeArticle
dspace.entity.typePublication
local.article.typeOriginal Article
oaire.citation.endPage46
oaire.citation.startPage42
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